Anti-ULBP6/ RAET1L monoclonal antibody

Anti-ULBP6/ RAET1L antibody for FACS & in-vivo assay

Target products collectionGo to RAET1L/RAET1L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1449-Ab-1/ GM-Tg-hg-MP1449-Ab-2Anti-Human RAET1L monoclonal antibodyHuman
GM-Tg-rg-MP1449-Ab-1/ GM-Tg-rg-MP1449-Ab-2Anti-Rat RAET1L monoclonal antibodyRat
GM-Tg-mg-MP1449-Ab-1/ GM-Tg-mg-MP1449-Ab-2Anti-Mouse RAET1L monoclonal antibodyMouse
GM-Tg-cynog-MP1449-Ab-1/ GM-Tg-cynog-MP1449-Ab-2Anti-Cynomolgus/ Rhesus macaque RAET1L monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1449-Ab-1/ GM-Tg-felg-MP1449-Ab-2Anti-Feline RAET1L monoclonal antibodyFeline
GM-Tg-cang-MP1449-Ab-1/ GM-Tg-cang-MP1449-Ab-2Anti-Canine RAET1L monoclonal antibodyCanine
GM-Tg-bovg-MP1449-Ab-1/ GM-Tg-bovg-MP1449-Ab-2Anti-Bovine RAET1L monoclonal antibodyBovine
GM-Tg-equg-MP1449-Ab-1/ GM-Tg-equg-MP1449-Ab-2Anti-Equine RAET1L monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1449-Ab-1/ GM-Tg-hg-MP1449-Ab-2; GM-Tg-rg-MP1449-Ab-1/ GM-Tg-rg-MP1449-Ab-2;
GM-Tg-mg-MP1449-Ab-1/ GM-Tg-mg-MP1449-Ab-2; GM-Tg-cynog-MP1449-Ab-1/ GM-Tg-cynog-MP1449-Ab-2;
GM-Tg-felg-MP1449-Ab-1/ GM-Tg-felg-MP1449-Ab-2; GM-Tg-cang-MP1449-Ab-1/ GM-Tg-cang-MP1449-Ab-2;
GM-Tg-bovg-MP1449-Ab-1/ GM-Tg-bovg-MP1449-Ab-2; GM-Tg-equg-MP1449-Ab-1/ GM-Tg-equg-MP1449-Ab-2
Products NameAnti-RAET1L monoclonal antibody
Formatmab
Target NameRAET1L
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RAET1L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ULBP6/ RAET1L VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1449
    Target NameRAET1L
    Gene ID154064
    Gene Symbol and SynonymsRAET1H,RAET1L,ULBP6
    Uniprot AccessionQ5VY80
    Uniprot Entry NameULBP6_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000155918
    Target ClassificationN/A

    The target: RAET1L, gene name: RAET1L, also named as ULBP6. RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.