Anti-R144A/ RNF144A/ RNF144 monoclonal antibody

Anti-R144A/ RNF144A/ RNF144 antibody for FACS & in-vivo assay

Target products collectionGo to RNF144A/RNF144A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1465-Ab-1/ GM-Tg-hg-MP1465-Ab-2Anti-Human RNF144A monoclonal antibodyHuman
GM-Tg-rg-MP1465-Ab-1/ GM-Tg-rg-MP1465-Ab-2Anti-Rat RNF144A monoclonal antibodyRat
GM-Tg-mg-MP1465-Ab-1/ GM-Tg-mg-MP1465-Ab-2Anti-Mouse RNF144A monoclonal antibodyMouse
GM-Tg-cynog-MP1465-Ab-1/ GM-Tg-cynog-MP1465-Ab-2Anti-Cynomolgus/ Rhesus macaque RNF144A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1465-Ab-1/ GM-Tg-felg-MP1465-Ab-2Anti-Feline RNF144A monoclonal antibodyFeline
GM-Tg-cang-MP1465-Ab-1/ GM-Tg-cang-MP1465-Ab-2Anti-Canine RNF144A monoclonal antibodyCanine
GM-Tg-bovg-MP1465-Ab-1/ GM-Tg-bovg-MP1465-Ab-2Anti-Bovine RNF144A monoclonal antibodyBovine
GM-Tg-equg-MP1465-Ab-1/ GM-Tg-equg-MP1465-Ab-2Anti-Equine RNF144A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1465-Ab-1/ GM-Tg-hg-MP1465-Ab-2; GM-Tg-rg-MP1465-Ab-1/ GM-Tg-rg-MP1465-Ab-2;
GM-Tg-mg-MP1465-Ab-1/ GM-Tg-mg-MP1465-Ab-2; GM-Tg-cynog-MP1465-Ab-1/ GM-Tg-cynog-MP1465-Ab-2;
GM-Tg-felg-MP1465-Ab-1/ GM-Tg-felg-MP1465-Ab-2; GM-Tg-cang-MP1465-Ab-1/ GM-Tg-cang-MP1465-Ab-2;
GM-Tg-bovg-MP1465-Ab-1/ GM-Tg-bovg-MP1465-Ab-2; GM-Tg-equg-MP1465-Ab-1/ GM-Tg-equg-MP1465-Ab-2
Products NameAnti-RNF144A monoclonal antibody
Formatmab
Target NameRNF144A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RNF144A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species R144A/ RNF144A/ RNF144 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1465
    Target NameRNF144A
    Gene ID9781,108089,500636,722223,609037,101090511,618176,100057284
    Gene Symbol and SynonymshUIP4,RGD1561737,RNF144,RNF144A,UBCE7IP4,UIP4
    Uniprot AccessionP50876
    Uniprot Entry NameR144A_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000151692
    Target ClassificationN/A

    The target: RNF144A, gene name: RNF144A, also named as RNF144, UBCE7IP4, hUIP4. This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.