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Anti-RTN3/ ASYIP/ HAP monoclonal antibody
Anti-RTN3/ ASYIP/ HAP antibody for FACS & in-vivo assay
Go to RTN3/RTN3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1470-Ab-1/ GM-Tg-hg-MP1470-Ab-2 | Anti-Human RTN3 monoclonal antibody | Human |
| GM-Tg-rg-MP1470-Ab-1/ GM-Tg-rg-MP1470-Ab-2 | Anti-Rat RTN3 monoclonal antibody | Rat |
| GM-Tg-mg-MP1470-Ab-1/ GM-Tg-mg-MP1470-Ab-2 | Anti-Mouse RTN3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1470-Ab-1/ GM-Tg-cynog-MP1470-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RTN3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1470-Ab-1/ GM-Tg-felg-MP1470-Ab-2 | Anti-Feline RTN3 monoclonal antibody | Feline |
| GM-Tg-cang-MP1470-Ab-1/ GM-Tg-cang-MP1470-Ab-2 | Anti-Canine RTN3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1470-Ab-1/ GM-Tg-bovg-MP1470-Ab-2 | Anti-Bovine RTN3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1470-Ab-1/ GM-Tg-equg-MP1470-Ab-2 | Anti-Equine RTN3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1470-Ab-1/ GM-Tg-hg-MP1470-Ab-2; GM-Tg-rg-MP1470-Ab-1/ GM-Tg-rg-MP1470-Ab-2; GM-Tg-mg-MP1470-Ab-1/ GM-Tg-mg-MP1470-Ab-2; GM-Tg-cynog-MP1470-Ab-1/ GM-Tg-cynog-MP1470-Ab-2; GM-Tg-felg-MP1470-Ab-1/ GM-Tg-felg-MP1470-Ab-2; GM-Tg-cang-MP1470-Ab-1/ GM-Tg-cang-MP1470-Ab-2; GM-Tg-bovg-MP1470-Ab-1/ GM-Tg-bovg-MP1470-Ab-2; GM-Tg-equg-MP1470-Ab-1/ GM-Tg-equg-MP1470-Ab-2 |
| Products Name | Anti-RTN3 monoclonal antibody |
| Format | mab |
| Target Name | RTN3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RTN3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RTN3/ ASYIP/ HAP VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1470 |
| Target Name | RTN3 |
| Gene ID | 10313,20168,140945,718173,476043,101094953,359721,100054417 |
| Gene Symbol and Synonyms | ASYIP,HAP,NSPL2,NSPLII,RTN3,RTN3-A1,RTN3w |
| Uniprot Accession | O95197,Q6RJR6,Q08D83 |
| Uniprot Entry Name | RTN3_HUMAN,RTN3_RAT,RTN3_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000133318 |
| Target Classification | N/A |
The target: RTN3, gene name: RTN3, also named as ASYIP, HAP, NSPL2, NSPLII-A1, RTN3. This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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