Anti-R4RL1/ RTN4RL1/ NGRH2 monoclonal antibody

Anti-R4RL1/ RTN4RL1/ NGRH2 antibody for FACS & in-vivo assay

Target products collectionGo to RTN4RL1/RTN4RL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1471-Ab-1/ GM-Tg-hg-MP1471-Ab-2Anti-Human RTN4RL1 monoclonal antibodyHuman
GM-Tg-rg-MP1471-Ab-1/ GM-Tg-rg-MP1471-Ab-2Anti-Rat RTN4RL1 monoclonal antibodyRat
GM-Tg-mg-MP1471-Ab-1/ GM-Tg-mg-MP1471-Ab-2Anti-Mouse RTN4RL1 monoclonal antibodyMouse
GM-Tg-cynog-MP1471-Ab-1/ GM-Tg-cynog-MP1471-Ab-2Anti-Cynomolgus/ Rhesus macaque RTN4RL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1471-Ab-1/ GM-Tg-felg-MP1471-Ab-2Anti-Feline RTN4RL1 monoclonal antibodyFeline
GM-Tg-cang-MP1471-Ab-1/ GM-Tg-cang-MP1471-Ab-2Anti-Canine RTN4RL1 monoclonal antibodyCanine
GM-Tg-bovg-MP1471-Ab-1/ GM-Tg-bovg-MP1471-Ab-2Anti-Bovine RTN4RL1 monoclonal antibodyBovine
GM-Tg-equg-MP1471-Ab-1/ GM-Tg-equg-MP1471-Ab-2Anti-Equine RTN4RL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1471-Ab-1/ GM-Tg-hg-MP1471-Ab-2; GM-Tg-rg-MP1471-Ab-1/ GM-Tg-rg-MP1471-Ab-2;
GM-Tg-mg-MP1471-Ab-1/ GM-Tg-mg-MP1471-Ab-2; GM-Tg-cynog-MP1471-Ab-1/ GM-Tg-cynog-MP1471-Ab-2;
GM-Tg-felg-MP1471-Ab-1/ GM-Tg-felg-MP1471-Ab-2; GM-Tg-cang-MP1471-Ab-1/ GM-Tg-cang-MP1471-Ab-2;
GM-Tg-bovg-MP1471-Ab-1/ GM-Tg-bovg-MP1471-Ab-2; GM-Tg-equg-MP1471-Ab-1/ GM-Tg-equg-MP1471-Ab-2
Products NameAnti-RTN4RL1 monoclonal antibody
Formatmab
Target NameRTN4RL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RTN4RL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species R4RL1/ RTN4RL1/ NGRH2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1471
    Target NameRTN4RL1
    Gene ID146760,237847,303311,720246,491197,101084068,539358,100072439
    Gene Symbol and SynonymsNgR3,NGRH2,Ngrl2,RTN4RL1
    Uniprot AccessionQ86UN2,Q80WD0
    Uniprot Entry NameR4RL1_HUMAN,R4RL1_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseBreast Cancer
    Gene EnsemblENSG00000185924
    Target ClassificationN/A

    The target: RTN4RL1, gene name: RTN4RL1, also named as NGRH2, NgR3. Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.