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Anti-RYK/ D3S3195/ JTK5 monoclonal antibody
Anti-RYK/ D3S3195/ JTK5 antibody for FACS & in-vivo assay
Go to RYK/RYK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1477-Ab-1/ GM-Tg-hg-MP1477-Ab-2 | Anti-Human RYK monoclonal antibody | Human |
| GM-Tg-rg-MP1477-Ab-1/ GM-Tg-rg-MP1477-Ab-2 | Anti-Rat RYK monoclonal antibody | Rat |
| GM-Tg-mg-MP1477-Ab-1/ GM-Tg-mg-MP1477-Ab-2 | Anti-Mouse RYK monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1477-Ab-1/ GM-Tg-cynog-MP1477-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RYK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1477-Ab-1/ GM-Tg-felg-MP1477-Ab-2 | Anti-Feline RYK monoclonal antibody | Feline |
| GM-Tg-cang-MP1477-Ab-1/ GM-Tg-cang-MP1477-Ab-2 | Anti-Canine RYK monoclonal antibody | Canine |
| GM-Tg-bovg-MP1477-Ab-1/ GM-Tg-bovg-MP1477-Ab-2 | Anti-Bovine RYK monoclonal antibody | Bovine |
| GM-Tg-equg-MP1477-Ab-1/ GM-Tg-equg-MP1477-Ab-2 | Anti-Equine RYK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1477-Ab-1/ GM-Tg-hg-MP1477-Ab-2; GM-Tg-rg-MP1477-Ab-1/ GM-Tg-rg-MP1477-Ab-2; GM-Tg-mg-MP1477-Ab-1/ GM-Tg-mg-MP1477-Ab-2; GM-Tg-cynog-MP1477-Ab-1/ GM-Tg-cynog-MP1477-Ab-2; GM-Tg-felg-MP1477-Ab-1/ GM-Tg-felg-MP1477-Ab-2; GM-Tg-cang-MP1477-Ab-1/ GM-Tg-cang-MP1477-Ab-2; GM-Tg-bovg-MP1477-Ab-1/ GM-Tg-bovg-MP1477-Ab-2; GM-Tg-equg-MP1477-Ab-1/ GM-Tg-equg-MP1477-Ab-2 |
| Products Name | Anti-RYK monoclonal antibody |
| Format | mab |
| Target Name | RYK |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RYK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RYK/ D3S3195/ JTK5 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1477 |
| Target Name | RYK |
| Gene ID | 6259,20187,140585,718950,477074,101086838,781353,100065602 |
| Gene Symbol and Synonyms | D3S3195,ERK-3,JTK5,JTK5A,RYK,RYK1,Vik |
| Uniprot Accession | P34925 |
| Uniprot Entry Name | RYK_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000163785 |
| Target Classification | N/A |
The target: RYK, gene name: RYK, also named as D3S3195, JTK5, JTK5A1, RYK. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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