Anti-SEM4A/ SEMA4A/ CORD10 monoclonal antibody

Anti-SEM4A/ SEMA4A/ CORD10 antibody for FACS & in-vivo assay

Target products collectionGo to SEMA4A/SEMA4A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1500-Ab-1/ GM-Tg-hg-MP1500-Ab-2Anti-Human SEMA4A monoclonal antibodyHuman
GM-Tg-rg-MP1500-Ab-1/ GM-Tg-rg-MP1500-Ab-2Anti-Rat SEMA4A monoclonal antibodyRat
GM-Tg-mg-MP1500-Ab-1/ GM-Tg-mg-MP1500-Ab-2Anti-Mouse SEMA4A monoclonal antibodyMouse
GM-Tg-cynog-MP1500-Ab-1/ GM-Tg-cynog-MP1500-Ab-2Anti-Cynomolgus/ Rhesus macaque SEMA4A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1500-Ab-1/ GM-Tg-felg-MP1500-Ab-2Anti-Feline SEMA4A monoclonal antibodyFeline
GM-Tg-cang-MP1500-Ab-1/ GM-Tg-cang-MP1500-Ab-2Anti-Canine SEMA4A monoclonal antibodyCanine
GM-Tg-bovg-MP1500-Ab-1/ GM-Tg-bovg-MP1500-Ab-2Anti-Bovine SEMA4A monoclonal antibodyBovine
GM-Tg-equg-MP1500-Ab-1/ GM-Tg-equg-MP1500-Ab-2Anti-Equine SEMA4A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1500-Ab-1/ GM-Tg-hg-MP1500-Ab-2; GM-Tg-rg-MP1500-Ab-1/ GM-Tg-rg-MP1500-Ab-2;
GM-Tg-mg-MP1500-Ab-1/ GM-Tg-mg-MP1500-Ab-2; GM-Tg-cynog-MP1500-Ab-1/ GM-Tg-cynog-MP1500-Ab-2;
GM-Tg-felg-MP1500-Ab-1/ GM-Tg-felg-MP1500-Ab-2; GM-Tg-cang-MP1500-Ab-1/ GM-Tg-cang-MP1500-Ab-2;
GM-Tg-bovg-MP1500-Ab-1/ GM-Tg-bovg-MP1500-Ab-2; GM-Tg-equg-MP1500-Ab-1/ GM-Tg-equg-MP1500-Ab-2
Products NameAnti-SEMA4A monoclonal antibody
Formatmab
Target NameSEMA4A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SEMA4A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SEM4A/ SEMA4A/ CORD10 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1500
    Target NameSEMA4A
    Gene ID64218,20351,310630,718191,490416,101084161,510239,100064005
    Gene Symbol and SynonymsCORD10,RP35,SEMA4A,SEMAB,SEMB
    Uniprot AccessionQ9H3S1,Q5EA85
    Uniprot Entry NameSEM4A_HUMAN,SEM4A_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000196189
    Target ClassificationN/A

    The target: SEMA4A, gene name: SEMA4A, also named as CORD10, RP35, SEMAB, SEMB. This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.