Anti-SIG10/ SIGLEC10/ PRO940 monoclonal antibody

Anti-SIG10/ SIGLEC10/ PRO940 antibody for FACS & in-vivo assay

Target products collectionGo to SIGLEC10/SIGLEC10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1517-Ab-1/ GM-Tg-hg-MP1517-Ab-2Anti-Human SIGLEC10 monoclonal antibodyHuman
GM-Tg-rg-MP1517-Ab-1/ GM-Tg-rg-MP1517-Ab-2Anti-Rat SIGLEC10 monoclonal antibodyRat
GM-Tg-mg-MP1517-Ab-1/ GM-Tg-mg-MP1517-Ab-2Anti-Mouse SIGLEC10 monoclonal antibodyMouse
GM-Tg-cynog-MP1517-Ab-1/ GM-Tg-cynog-MP1517-Ab-2Anti-Cynomolgus/ Rhesus macaque SIGLEC10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1517-Ab-1/ GM-Tg-felg-MP1517-Ab-2Anti-Feline SIGLEC10 monoclonal antibodyFeline
GM-Tg-cang-MP1517-Ab-1/ GM-Tg-cang-MP1517-Ab-2Anti-Canine SIGLEC10 monoclonal antibodyCanine
GM-Tg-bovg-MP1517-Ab-1/ GM-Tg-bovg-MP1517-Ab-2Anti-Bovine SIGLEC10 monoclonal antibodyBovine
GM-Tg-equg-MP1517-Ab-1/ GM-Tg-equg-MP1517-Ab-2Anti-Equine SIGLEC10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1517-Ab-1/ GM-Tg-hg-MP1517-Ab-2; GM-Tg-rg-MP1517-Ab-1/ GM-Tg-rg-MP1517-Ab-2;
GM-Tg-mg-MP1517-Ab-1/ GM-Tg-mg-MP1517-Ab-2; GM-Tg-cynog-MP1517-Ab-1/ GM-Tg-cynog-MP1517-Ab-2;
GM-Tg-felg-MP1517-Ab-1/ GM-Tg-felg-MP1517-Ab-2; GM-Tg-cang-MP1517-Ab-1/ GM-Tg-cang-MP1517-Ab-2;
GM-Tg-bovg-MP1517-Ab-1/ GM-Tg-bovg-MP1517-Ab-2; GM-Tg-equg-MP1517-Ab-1/ GM-Tg-equg-MP1517-Ab-2
Products NameAnti-SIGLEC10 monoclonal antibody
Formatmab
Target NameSIGLEC10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SIGLEC10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SIG10/ SIGLEC10/ PRO940 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1517
    Target NameSIGLEC10
    Gene ID89790,719648
    Gene Symbol and SynonymsPRO940,SIGLEC-10,SIGLEC10,SLG2
    Uniprot AccessionQ96LC7
    Uniprot Entry NameSIG10_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000142512
    Target ClassificationN/A

    The target: SIGLEC10, gene name: SIGLEC10, also named as PRO940, SIGLEC-10, SLG2. SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.