Anti-SN/ SIGLEC1/ CD169 monoclonal antibody

Anti-SN/ SIGLEC1/ CD169 antibody for FACS & in-vivo assay

Target products collectionGo to SIGLEC1/SIGLEC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1518-Ab-1/ GM-Tg-hg-MP1518-Ab-2Anti-Human SIGLEC1 monoclonal antibodyHuman
GM-Tg-rg-MP1518-Ab-1/ GM-Tg-rg-MP1518-Ab-2Anti-Rat SIGLEC1 monoclonal antibodyRat
GM-Tg-mg-MP1518-Ab-1/ GM-Tg-mg-MP1518-Ab-2Anti-Mouse SIGLEC1 monoclonal antibodyMouse
GM-Tg-cynog-MP1518-Ab-1/ GM-Tg-cynog-MP1518-Ab-2Anti-Cynomolgus/ Rhesus macaque SIGLEC1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1518-Ab-1/ GM-Tg-felg-MP1518-Ab-2Anti-Feline SIGLEC1 monoclonal antibodyFeline
GM-Tg-cang-MP1518-Ab-1/ GM-Tg-cang-MP1518-Ab-2Anti-Canine SIGLEC1 monoclonal antibodyCanine
GM-Tg-bovg-MP1518-Ab-1/ GM-Tg-bovg-MP1518-Ab-2Anti-Bovine SIGLEC1 monoclonal antibodyBovine
GM-Tg-equg-MP1518-Ab-1/ GM-Tg-equg-MP1518-Ab-2Anti-Equine SIGLEC1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1518-Ab-1/ GM-Tg-hg-MP1518-Ab-2; GM-Tg-rg-MP1518-Ab-1/ GM-Tg-rg-MP1518-Ab-2;
GM-Tg-mg-MP1518-Ab-1/ GM-Tg-mg-MP1518-Ab-2; GM-Tg-cynog-MP1518-Ab-1/ GM-Tg-cynog-MP1518-Ab-2;
GM-Tg-felg-MP1518-Ab-1/ GM-Tg-felg-MP1518-Ab-2; GM-Tg-cang-MP1518-Ab-1/ GM-Tg-cang-MP1518-Ab-2;
GM-Tg-bovg-MP1518-Ab-1/ GM-Tg-bovg-MP1518-Ab-2; GM-Tg-equg-MP1518-Ab-1/ GM-Tg-equg-MP1518-Ab-2
Products NameAnti-SIGLEC1 monoclonal antibody
Formatmab
Target NameSIGLEC1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SIGLEC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SN/ SIGLEC1/ CD169 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1518
    Target NameSIGLEC1
    Gene ID6614,20612,311426,717470,485794,101093264,539759,100066351
    Gene Symbol and SynonymsCD169,SIGLEC-1,SIGLEC1,SN
    Uniprot AccessionQ9BZZ2
    Uniprot Entry NameSN_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000088827
    Target ClassificationN/A

    The target: SIGLEC1, gene name: SIGLEC1, also named as CD169, SIGLEC-1, SN, dJ1009E24.1. This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection. [provided by RefSeq, Dec 2021].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.