Anti-SIG11/ SIGLEC11 monoclonal antibody

Anti-SIG11/ SIGLEC11 antibody for FACS & in-vivo assay

Target products collectionGo to SIGLEC11/SIGLEC11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1519-Ab-1/ GM-Tg-hg-MP1519-Ab-2Anti-Human SIGLEC11 monoclonal antibodyHuman
GM-Tg-rg-MP1519-Ab-1/ GM-Tg-rg-MP1519-Ab-2Anti-Rat SIGLEC11 monoclonal antibodyRat
GM-Tg-mg-MP1519-Ab-1/ GM-Tg-mg-MP1519-Ab-2Anti-Mouse SIGLEC11 monoclonal antibodyMouse
GM-Tg-cynog-MP1519-Ab-1/ GM-Tg-cynog-MP1519-Ab-2Anti-Cynomolgus/ Rhesus macaque SIGLEC11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1519-Ab-1/ GM-Tg-felg-MP1519-Ab-2Anti-Feline SIGLEC11 monoclonal antibodyFeline
GM-Tg-cang-MP1519-Ab-1/ GM-Tg-cang-MP1519-Ab-2Anti-Canine SIGLEC11 monoclonal antibodyCanine
GM-Tg-bovg-MP1519-Ab-1/ GM-Tg-bovg-MP1519-Ab-2Anti-Bovine SIGLEC11 monoclonal antibodyBovine
GM-Tg-equg-MP1519-Ab-1/ GM-Tg-equg-MP1519-Ab-2Anti-Equine SIGLEC11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1519-Ab-1/ GM-Tg-hg-MP1519-Ab-2; GM-Tg-rg-MP1519-Ab-1/ GM-Tg-rg-MP1519-Ab-2;
GM-Tg-mg-MP1519-Ab-1/ GM-Tg-mg-MP1519-Ab-2; GM-Tg-cynog-MP1519-Ab-1/ GM-Tg-cynog-MP1519-Ab-2;
GM-Tg-felg-MP1519-Ab-1/ GM-Tg-felg-MP1519-Ab-2; GM-Tg-cang-MP1519-Ab-1/ GM-Tg-cang-MP1519-Ab-2;
GM-Tg-bovg-MP1519-Ab-1/ GM-Tg-bovg-MP1519-Ab-2; GM-Tg-equg-MP1519-Ab-1/ GM-Tg-equg-MP1519-Ab-2
Products NameAnti-SIGLEC11 monoclonal antibody
Formatmab
Target NameSIGLEC11
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SIGLEC11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SIG11/ SIGLEC11 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1519
    Target NameSIGLEC11
    Gene ID114132,719127,484368,101100429,511180,100147018
    Gene Symbol and SynonymsSIGLEC11
    Uniprot AccessionQ96RL6
    Uniprot Entry NameSIG11_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000161640
    Target ClassificationN/A

    The target: SIGLEC11, gene name: SIGLEC11, also named as . This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.