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Anti-SIG12/ SIGLEC12/ S2V monoclonal antibody
Anti-SIG12/ SIGLEC12/ S2V antibody for FACS & in-vivo assay
Go to SIGLEC12/SIGLEC12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1520-Ab-1/ GM-Tg-hg-MP1520-Ab-2 | Anti-Human SIGLEC12 monoclonal antibody | Human |
| GM-Tg-rg-MP1520-Ab-1/ GM-Tg-rg-MP1520-Ab-2 | Anti-Rat SIGLEC12 monoclonal antibody | Rat |
| GM-Tg-mg-MP1520-Ab-1/ GM-Tg-mg-MP1520-Ab-2 | Anti-Mouse SIGLEC12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1520-Ab-1/ GM-Tg-cynog-MP1520-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SIGLEC12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1520-Ab-1/ GM-Tg-felg-MP1520-Ab-2 | Anti-Feline SIGLEC12 monoclonal antibody | Feline |
| GM-Tg-cang-MP1520-Ab-1/ GM-Tg-cang-MP1520-Ab-2 | Anti-Canine SIGLEC12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1520-Ab-1/ GM-Tg-bovg-MP1520-Ab-2 | Anti-Bovine SIGLEC12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1520-Ab-1/ GM-Tg-equg-MP1520-Ab-2 | Anti-Equine SIGLEC12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1520-Ab-1/ GM-Tg-hg-MP1520-Ab-2; GM-Tg-rg-MP1520-Ab-1/ GM-Tg-rg-MP1520-Ab-2; GM-Tg-mg-MP1520-Ab-1/ GM-Tg-mg-MP1520-Ab-2; GM-Tg-cynog-MP1520-Ab-1/ GM-Tg-cynog-MP1520-Ab-2; GM-Tg-felg-MP1520-Ab-1/ GM-Tg-felg-MP1520-Ab-2; GM-Tg-cang-MP1520-Ab-1/ GM-Tg-cang-MP1520-Ab-2; GM-Tg-bovg-MP1520-Ab-1/ GM-Tg-bovg-MP1520-Ab-2; GM-Tg-equg-MP1520-Ab-1/ GM-Tg-equg-MP1520-Ab-2 |
| Products Name | Anti-SIGLEC12 monoclonal antibody |
| Format | mab |
| Target Name | SIGLEC12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SIGLEC12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SIG12/ SIGLEC12/ S2V VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1520 |
| Target Name | SIGLEC12 |
| Gene ID | 89858,719654 |
| Gene Symbol and Synonyms | S2V,Siglec-XII,SIGLEC12,SIGLECL1,SLG |
| Uniprot Accession | Q96PQ1 |
| Uniprot Entry Name | SIG12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000254521 |
| Target Classification | N/A |
The target: SIGLEC12, gene name: SIGLEC12, also named as S2V, SIGLECL1, SLG, Siglec-XII. Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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