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Anti-SIGL8/ SIGLEC8/ SAF2 monoclonal antibody
Anti-SIGL8/ SIGLEC8/ SAF2 antibody for FACS & in-vivo assay
Go to SIGLEC8/SIGLEC8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1525-Ab-1/ GM-Tg-hg-MP1525-Ab-2 | Anti-Human SIGLEC8 monoclonal antibody | Human |
| GM-Tg-rg-MP1525-Ab-1/ GM-Tg-rg-MP1525-Ab-2 | Anti-Rat SIGLEC8 monoclonal antibody | Rat |
| GM-Tg-mg-MP1525-Ab-1/ GM-Tg-mg-MP1525-Ab-2 | Anti-Mouse SIGLEC8 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1525-Ab-1/ GM-Tg-cynog-MP1525-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SIGLEC8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1525-Ab-1/ GM-Tg-felg-MP1525-Ab-2 | Anti-Feline SIGLEC8 monoclonal antibody | Feline |
| GM-Tg-cang-MP1525-Ab-1/ GM-Tg-cang-MP1525-Ab-2 | Anti-Canine SIGLEC8 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1525-Ab-1/ GM-Tg-bovg-MP1525-Ab-2 | Anti-Bovine SIGLEC8 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1525-Ab-1/ GM-Tg-equg-MP1525-Ab-2 | Anti-Equine SIGLEC8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1525-Ab-1/ GM-Tg-hg-MP1525-Ab-2; GM-Tg-rg-MP1525-Ab-1/ GM-Tg-rg-MP1525-Ab-2; GM-Tg-mg-MP1525-Ab-1/ GM-Tg-mg-MP1525-Ab-2; GM-Tg-cynog-MP1525-Ab-1/ GM-Tg-cynog-MP1525-Ab-2; GM-Tg-felg-MP1525-Ab-1/ GM-Tg-felg-MP1525-Ab-2; GM-Tg-cang-MP1525-Ab-1/ GM-Tg-cang-MP1525-Ab-2; GM-Tg-bovg-MP1525-Ab-1/ GM-Tg-bovg-MP1525-Ab-2; GM-Tg-equg-MP1525-Ab-1/ GM-Tg-equg-MP1525-Ab-2 |
| Products Name | Anti-SIGLEC8 monoclonal antibody |
| Format | mab |
| Target Name | SIGLEC8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SIGLEC8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-315 | Pre-Made Lirentelimab biosimilar, Whole mAb, Anti-SIGLEC8/Siglec-8 Antibody: Anti-SAF2 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species SIGL8/ SIGLEC8/ SAF2 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1525 |
| Target Name | SIGLEC8 |
| Gene ID | 27181,506364 |
| Gene Symbol and Synonyms | SAF2,SIGLEC-8,SIGLEC8,SIGLEC8L |
| Uniprot Accession | Q9NYZ4 |
| Uniprot Entry Name | SIGL8_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000105366 |
| Target Classification | N/A |
The target: SIGLEC8, gene name: SIGLEC8, also named as SAF2, SIGLEC-8L, SIGLEC8. Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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