- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-NRAM1/ SLC11A1/ LSH monoclonal antibody
Anti-NRAM1/ SLC11A1/ LSH antibody for FACS & in-vivo assay
Go to SLC11A1/SLC11A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1534-Ab-1/ GM-Tg-hg-MP1534-Ab-2 | Anti-Human SLC11A1 monoclonal antibody | Human |
| GM-Tg-rg-MP1534-Ab-1/ GM-Tg-rg-MP1534-Ab-2 | Anti-Rat SLC11A1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1534-Ab-1/ GM-Tg-mg-MP1534-Ab-2 | Anti-Mouse SLC11A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1534-Ab-1/ GM-Tg-cynog-MP1534-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC11A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1534-Ab-1/ GM-Tg-felg-MP1534-Ab-2 | Anti-Feline SLC11A1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1534-Ab-1/ GM-Tg-cang-MP1534-Ab-2 | Anti-Canine SLC11A1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1534-Ab-1/ GM-Tg-bovg-MP1534-Ab-2 | Anti-Bovine SLC11A1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1534-Ab-1/ GM-Tg-equg-MP1534-Ab-2 | Anti-Equine SLC11A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1534-Ab-1/ GM-Tg-hg-MP1534-Ab-2; GM-Tg-rg-MP1534-Ab-1/ GM-Tg-rg-MP1534-Ab-2; GM-Tg-mg-MP1534-Ab-1/ GM-Tg-mg-MP1534-Ab-2; GM-Tg-cynog-MP1534-Ab-1/ GM-Tg-cynog-MP1534-Ab-2; GM-Tg-felg-MP1534-Ab-1/ GM-Tg-felg-MP1534-Ab-2; GM-Tg-cang-MP1534-Ab-1/ GM-Tg-cang-MP1534-Ab-2; GM-Tg-bovg-MP1534-Ab-1/ GM-Tg-bovg-MP1534-Ab-2; GM-Tg-equg-MP1534-Ab-1/ GM-Tg-equg-MP1534-Ab-2 |
| Products Name | Anti-SLC11A1 monoclonal antibody |
| Format | mab |
| Target Name | SLC11A1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC11A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NRAM1/ SLC11A1/ LSH VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm005426 | mouse Slc11a1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005426 | mouse Slc11a1 Lentivirus particle |
Target information
| Target ID | GM-MP1534 |
| Target Name | SLC11A1 |
| Gene ID | 6556,18173,316519,701025,478909,101089954,282470,100033912 |
| Gene Symbol and Synonyms | Bcg,Itg,Ity,Ity1,LSH,NRAMP,NRAMP1,SLC11A1 |
| Uniprot Accession | P49279,P70553,Q9XT74,Q27981 |
| Uniprot Entry Name | NRAM1_HUMAN,NRAM1_RAT,NRAM1_CANLF,NRAM1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000018280 |
| Target Classification | N/A |
The target: SLC11A1, gene name: SLC11A1, also named as LSH, NRAMP, NRAMP1. This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
