Anti-S22A1/ SLC22A1/ HOCT1 monoclonal antibody

Anti-S22A1/ SLC22A1/ HOCT1 antibody for FACS & in-vivo assay

Target products collectionGo to SLC22A1/SLC22A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1555-Ab-1/ GM-Tg-hg-MP1555-Ab-2Anti-Human SLC22A1 monoclonal antibodyHuman
GM-Tg-rg-MP1555-Ab-1/ GM-Tg-rg-MP1555-Ab-2Anti-Rat SLC22A1 monoclonal antibodyRat
GM-Tg-mg-MP1555-Ab-1/ GM-Tg-mg-MP1555-Ab-2Anti-Mouse SLC22A1 monoclonal antibodyMouse
GM-Tg-cynog-MP1555-Ab-1/ GM-Tg-cynog-MP1555-Ab-2Anti-Cynomolgus/ Rhesus macaque SLC22A1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1555-Ab-1/ GM-Tg-felg-MP1555-Ab-2Anti-Feline SLC22A1 monoclonal antibodyFeline
GM-Tg-cang-MP1555-Ab-1/ GM-Tg-cang-MP1555-Ab-2Anti-Canine SLC22A1 monoclonal antibodyCanine
GM-Tg-bovg-MP1555-Ab-1/ GM-Tg-bovg-MP1555-Ab-2Anti-Bovine SLC22A1 monoclonal antibodyBovine
GM-Tg-equg-MP1555-Ab-1/ GM-Tg-equg-MP1555-Ab-2Anti-Equine SLC22A1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1555-Ab-1/ GM-Tg-hg-MP1555-Ab-2; GM-Tg-rg-MP1555-Ab-1/ GM-Tg-rg-MP1555-Ab-2;
GM-Tg-mg-MP1555-Ab-1/ GM-Tg-mg-MP1555-Ab-2; GM-Tg-cynog-MP1555-Ab-1/ GM-Tg-cynog-MP1555-Ab-2;
GM-Tg-felg-MP1555-Ab-1/ GM-Tg-felg-MP1555-Ab-2; GM-Tg-cang-MP1555-Ab-1/ GM-Tg-cang-MP1555-Ab-2;
GM-Tg-bovg-MP1555-Ab-1/ GM-Tg-bovg-MP1555-Ab-2; GM-Tg-equg-MP1555-Ab-1/ GM-Tg-equg-MP1555-Ab-2
Products NameAnti-SLC22A1 monoclonal antibody
Formatmab
Target NameSLC22A1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SLC22A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species S22A1/ SLC22A1/ HOCT1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1555
    Target NameSLC22A1
    Gene ID6580,24904,703449,484068,101094761,519461,100058455
    Gene Symbol and SynonymsHOCT1,OCT1,oct1_cds,Orct1,Roct1,SLC22A1
    Uniprot AccessionO15245,Q63089,A7MBE0
    Uniprot Entry NameS22A1_HUMAN,S22A1_RAT,S22A1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000175003
    Target ClassificationN/A

    The target: SLC22A1, gene name: SLC22A1, also named as HOCT1, OCT1, oct1_cds. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.