Anti-NCKX2/ SLC24A2 monoclonal antibody

Anti-NCKX2/ SLC24A2 antibody for FACS & in-vivo assay

Target products collectionGo to SLC24A2/SLC24A2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1568-Ab-1/ GM-Tg-hg-MP1568-Ab-2Anti-Human SLC24A2 monoclonal antibodyHuman
GM-Tg-rg-MP1568-Ab-1/ GM-Tg-rg-MP1568-Ab-2Anti-Rat SLC24A2 monoclonal antibodyRat
GM-Tg-mg-MP1568-Ab-1/ GM-Tg-mg-MP1568-Ab-2Anti-Mouse SLC24A2 monoclonal antibodyMouse
GM-Tg-cynog-MP1568-Ab-1/ GM-Tg-cynog-MP1568-Ab-2Anti-Cynomolgus/ Rhesus macaque SLC24A2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1568-Ab-1/ GM-Tg-felg-MP1568-Ab-2Anti-Feline SLC24A2 monoclonal antibodyFeline
GM-Tg-cang-MP1568-Ab-1/ GM-Tg-cang-MP1568-Ab-2Anti-Canine SLC24A2 monoclonal antibodyCanine
GM-Tg-bovg-MP1568-Ab-1/ GM-Tg-bovg-MP1568-Ab-2Anti-Bovine SLC24A2 monoclonal antibodyBovine
GM-Tg-equg-MP1568-Ab-1/ GM-Tg-equg-MP1568-Ab-2Anti-Equine SLC24A2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1568-Ab-1/ GM-Tg-hg-MP1568-Ab-2; GM-Tg-rg-MP1568-Ab-1/ GM-Tg-rg-MP1568-Ab-2;
GM-Tg-mg-MP1568-Ab-1/ GM-Tg-mg-MP1568-Ab-2; GM-Tg-cynog-MP1568-Ab-1/ GM-Tg-cynog-MP1568-Ab-2;
GM-Tg-felg-MP1568-Ab-1/ GM-Tg-felg-MP1568-Ab-2; GM-Tg-cang-MP1568-Ab-1/ GM-Tg-cang-MP1568-Ab-2;
GM-Tg-bovg-MP1568-Ab-1/ GM-Tg-bovg-MP1568-Ab-2; GM-Tg-equg-MP1568-Ab-1/ GM-Tg-equg-MP1568-Ab-2
Products NameAnti-SLC24A2 monoclonal antibody
Formatmab
Target NameSLC24A2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SLC24A2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NCKX2/ SLC24A2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1568
    Target NameSLC24A2
    Gene ID25769,76376,84550,711896,481554,101098994,525618,100063961
    Gene Symbol and Synonyms2810021B17Rik,6330417K15Rik,NCKX2,SLC24A2
    Uniprot AccessionQ9UI40,O54701
    Uniprot Entry NameNCKX2_HUMAN,NCKX2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000155886
    Target ClassificationN/A

    The target: SLC24A2, gene name: SLC24A2, also named as NCKX2. This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.