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Anti-S26A5/ SLC26A5/ DFNB61 monoclonal antibody
Anti-S26A5/ SLC26A5/ DFNB61 antibody for FACS & in-vivo assay
Go to SLC26A5/SLC26A5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1576-Ab-1/ GM-Tg-hg-MP1576-Ab-2 | Anti-Human SLC26A5 monoclonal antibody | Human |
| GM-Tg-rg-MP1576-Ab-1/ GM-Tg-rg-MP1576-Ab-2 | Anti-Rat SLC26A5 monoclonal antibody | Rat |
| GM-Tg-mg-MP1576-Ab-1/ GM-Tg-mg-MP1576-Ab-2 | Anti-Mouse SLC26A5 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1576-Ab-1/ GM-Tg-cynog-MP1576-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC26A5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1576-Ab-1/ GM-Tg-felg-MP1576-Ab-2 | Anti-Feline SLC26A5 monoclonal antibody | Feline |
| GM-Tg-cang-MP1576-Ab-1/ GM-Tg-cang-MP1576-Ab-2 | Anti-Canine SLC26A5 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1576-Ab-1/ GM-Tg-bovg-MP1576-Ab-2 | Anti-Bovine SLC26A5 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1576-Ab-1/ GM-Tg-equg-MP1576-Ab-2 | Anti-Equine SLC26A5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1576-Ab-1/ GM-Tg-hg-MP1576-Ab-2; GM-Tg-rg-MP1576-Ab-1/ GM-Tg-rg-MP1576-Ab-2; GM-Tg-mg-MP1576-Ab-1/ GM-Tg-mg-MP1576-Ab-2; GM-Tg-cynog-MP1576-Ab-1/ GM-Tg-cynog-MP1576-Ab-2; GM-Tg-felg-MP1576-Ab-1/ GM-Tg-felg-MP1576-Ab-2; GM-Tg-cang-MP1576-Ab-1/ GM-Tg-cang-MP1576-Ab-2; GM-Tg-bovg-MP1576-Ab-1/ GM-Tg-bovg-MP1576-Ab-2; GM-Tg-equg-MP1576-Ab-1/ GM-Tg-equg-MP1576-Ab-2 |
| Products Name | Anti-SLC26A5 monoclonal antibody |
| Format | mab |
| Target Name | SLC26A5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC26A5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S26A5/ SLC26A5/ DFNB61 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1576 |
| Target Name | SLC26A5 |
| Gene ID | 375611,80979,83819,696074,483274,100192303,536341,100058502 |
| Gene Symbol and Synonyms | DFNB61,PRES,prestin,SLC26A5 |
| Uniprot Accession | P58743,Q9EPH0 |
| Uniprot Entry Name | S26A5_HUMAN,S26A5_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000170615 |
| Target Classification | N/A |
The target: SLC26A5, gene name: SLC26A5, also named as DFNB61, PRES. This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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