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Anti-S29A2/ SLC29A2/ DER12 monoclonal antibody
Anti-S29A2/ SLC29A2/ DER12 antibody for FACS & in-vivo assay
Go to SLC29A2/SLC29A2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1586-Ab-1/ GM-Tg-hg-MP1586-Ab-2 | Anti-Human SLC29A2 monoclonal antibody | Human |
| GM-Tg-rg-MP1586-Ab-1/ GM-Tg-rg-MP1586-Ab-2 | Anti-Rat SLC29A2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1586-Ab-1/ GM-Tg-mg-MP1586-Ab-2 | Anti-Mouse SLC29A2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1586-Ab-1/ GM-Tg-cynog-MP1586-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC29A2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1586-Ab-1/ GM-Tg-felg-MP1586-Ab-2 | Anti-Feline SLC29A2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1586-Ab-1/ GM-Tg-cang-MP1586-Ab-2 | Anti-Canine SLC29A2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1586-Ab-1/ GM-Tg-bovg-MP1586-Ab-2 | Anti-Bovine SLC29A2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1586-Ab-1/ GM-Tg-equg-MP1586-Ab-2 | Anti-Equine SLC29A2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1586-Ab-1/ GM-Tg-hg-MP1586-Ab-2; GM-Tg-rg-MP1586-Ab-1/ GM-Tg-rg-MP1586-Ab-2; GM-Tg-mg-MP1586-Ab-1/ GM-Tg-mg-MP1586-Ab-2; GM-Tg-cynog-MP1586-Ab-1/ GM-Tg-cynog-MP1586-Ab-2; GM-Tg-felg-MP1586-Ab-1/ GM-Tg-felg-MP1586-Ab-2; GM-Tg-cang-MP1586-Ab-1/ GM-Tg-cang-MP1586-Ab-2; GM-Tg-bovg-MP1586-Ab-1/ GM-Tg-bovg-MP1586-Ab-2; GM-Tg-equg-MP1586-Ab-1/ GM-Tg-equg-MP1586-Ab-2 |
| Products Name | Anti-SLC29A2 monoclonal antibody |
| Format | mab |
| Target Name | SLC29A2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC29A2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-783 | Pre-Made Clervonafusp Alfa Biosimilar, Fusion Protein targeting SLC29A2/ENT2 fused with human GAA (glucosidase alpha, acid, lysosomal alpha-glucosidase )(Pr67-952) (1:2) Enzyme substitute: Recombinant therapeutic protein targeting DER12/HNP36 |
| Biosimilar | GMP-Bios-ab-111 | Pre-Made Clervonafusp biosimilar, di-Fab Fusion, Anti-SLC29A2/ENT2 Antibody: Anti-DER12/HNP36 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species S29A2/ SLC29A2/ DER12 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1586 |
| Target Name | SLC29A2 |
| Gene ID | 3177,13340,65194,720038,611913,101084828,531564,100052412 |
| Gene Symbol and Synonyms | DER12,ENT2,HNP36,SLC29A2 |
| Uniprot Accession | Q14542,O54699 |
| Uniprot Entry Name | S29A2_HUMAN,S29A2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000174669 |
| Target Classification | N/A |
The target: SLC29A2, gene name: SLC29A2, also named as DER12, ENT2, HNP36. The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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