Anti-S4A5/ SLC4A5/ NBC4 monoclonal antibody

Anti-S4A5/ SLC4A5/ NBC4 antibody for FACS & in-vivo assay

Target products collectionGo to SLC4A5/SLC4A5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1639-Ab-1/ GM-Tg-hg-MP1639-Ab-2Anti-Human SLC4A5 monoclonal antibodyHuman
GM-Tg-rg-MP1639-Ab-1/ GM-Tg-rg-MP1639-Ab-2Anti-Rat SLC4A5 monoclonal antibodyRat
GM-Tg-mg-MP1639-Ab-1/ GM-Tg-mg-MP1639-Ab-2Anti-Mouse SLC4A5 monoclonal antibodyMouse
GM-Tg-cynog-MP1639-Ab-1/ GM-Tg-cynog-MP1639-Ab-2Anti-Cynomolgus/ Rhesus macaque SLC4A5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1639-Ab-1/ GM-Tg-felg-MP1639-Ab-2Anti-Feline SLC4A5 monoclonal antibodyFeline
GM-Tg-cang-MP1639-Ab-1/ GM-Tg-cang-MP1639-Ab-2Anti-Canine SLC4A5 monoclonal antibodyCanine
GM-Tg-bovg-MP1639-Ab-1/ GM-Tg-bovg-MP1639-Ab-2Anti-Bovine SLC4A5 monoclonal antibodyBovine
GM-Tg-equg-MP1639-Ab-1/ GM-Tg-equg-MP1639-Ab-2Anti-Equine SLC4A5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1639-Ab-1/ GM-Tg-hg-MP1639-Ab-2; GM-Tg-rg-MP1639-Ab-1/ GM-Tg-rg-MP1639-Ab-2;
GM-Tg-mg-MP1639-Ab-1/ GM-Tg-mg-MP1639-Ab-2; GM-Tg-cynog-MP1639-Ab-1/ GM-Tg-cynog-MP1639-Ab-2;
GM-Tg-felg-MP1639-Ab-1/ GM-Tg-felg-MP1639-Ab-2; GM-Tg-cang-MP1639-Ab-1/ GM-Tg-cang-MP1639-Ab-2;
GM-Tg-bovg-MP1639-Ab-1/ GM-Tg-bovg-MP1639-Ab-2; GM-Tg-equg-MP1639-Ab-1/ GM-Tg-equg-MP1639-Ab-2
Products NameAnti-SLC4A5 monoclonal antibody
Formatmab
Target NameSLC4A5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SLC4A5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species S4A5/ SLC4A5/ NBC4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1639
    Target NameSLC4A5
    Gene ID57835,232156,297386,715025,612275,101084098,100297538,100069223
    Gene Symbol and SynonymsC330006M16,C330016K18Rik,NBC4,NBCe2,SLC4A5
    Uniprot AccessionQ9BY07,Q6RI88
    Uniprot Entry NameS4A5_HUMAN,S4A5_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000188687
    Target ClassificationN/A

    The target: SLC4A5, gene name: SLC4A5, also named as NBC4, NBCe2. This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.