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Anti-S6A19/ SLC6A19/ B0AT1 monoclonal antibody
Anti-S6A19/ SLC6A19/ B0AT1 antibody for FACS & in-vivo assay
Go to SLC6A19/SLC6A19 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1657-Ab-1/ GM-Tg-hg-MP1657-Ab-2 | Anti-Human SLC6A19 monoclonal antibody | Human |
| GM-Tg-rg-MP1657-Ab-1/ GM-Tg-rg-MP1657-Ab-2 | Anti-Rat SLC6A19 monoclonal antibody | Rat |
| GM-Tg-mg-MP1657-Ab-1/ GM-Tg-mg-MP1657-Ab-2 | Anti-Mouse SLC6A19 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1657-Ab-1/ GM-Tg-cynog-MP1657-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLC6A19 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1657-Ab-1/ GM-Tg-felg-MP1657-Ab-2 | Anti-Feline SLC6A19 monoclonal antibody | Feline |
| GM-Tg-cang-MP1657-Ab-1/ GM-Tg-cang-MP1657-Ab-2 | Anti-Canine SLC6A19 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1657-Ab-1/ GM-Tg-bovg-MP1657-Ab-2 | Anti-Bovine SLC6A19 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1657-Ab-1/ GM-Tg-equg-MP1657-Ab-2 | Anti-Equine SLC6A19 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1657-Ab-1/ GM-Tg-hg-MP1657-Ab-2; GM-Tg-rg-MP1657-Ab-1/ GM-Tg-rg-MP1657-Ab-2; GM-Tg-mg-MP1657-Ab-1/ GM-Tg-mg-MP1657-Ab-2; GM-Tg-cynog-MP1657-Ab-1/ GM-Tg-cynog-MP1657-Ab-2; GM-Tg-felg-MP1657-Ab-1/ GM-Tg-felg-MP1657-Ab-2; GM-Tg-cang-MP1657-Ab-1/ GM-Tg-cang-MP1657-Ab-2; GM-Tg-bovg-MP1657-Ab-1/ GM-Tg-bovg-MP1657-Ab-2; GM-Tg-equg-MP1657-Ab-1/ GM-Tg-equg-MP1657-Ab-2 |
| Products Name | Anti-SLC6A19 monoclonal antibody |
| Format | mab |
| Target Name | SLC6A19 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLC6A19 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S6A19/ SLC6A19/ B0AT1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001736 | human SLC6A19 Lentivirus particle |
| ORF Viral Vector | pGMLP001736 | human SLC6A19 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002729 | mouse Slc6a19 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002729 | mouse Slc6a19 Lentivirus particle |
Target information
| Target ID | GM-MP1657 |
| Target Name | SLC6A19 |
| Gene ID | 340024,74338,664630,100424683,100683912,123380628,100337416,100069470 |
| Gene Symbol and Synonyms | 4632401C08Rik,B0AT1,B<0>AT1,HND,SLC6A19 |
| Uniprot Accession | Q695T7,Q2A865 |
| Uniprot Entry Name | S6A19_HUMAN,S6A19_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000174358 |
| Target Classification | N/A |
The target: SLC6A19, gene name: SLC6A19, also named as B0AT1, HND. This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene may result in Hartnup disorder, an inherited disease with symptoms such as pellagra, cerebellar ataxia, and psychosis. The expression and function of B0AT1 (SLC6A19) in intestinal cells depends on the presence of the accessory protein angiotensin-converting enzyme 2 (ACE2) which, among other functions, acts as a chaperone for membrane trafficking of B0AT1. The ACE2 is also the cellular receptor for severe acute respiratory syndrome-coronavirus (SARS-CoV) and for SARS-CoV-2 that is causing the coronavirus 2019 (COVID-19) pandemic [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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