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Anti-SORC3/ SORCS3/ SORCS monoclonal antibody
Anti-SORC3/ SORCS3/ SORCS antibody for FACS & in-vivo assay
Go to SORCS3/SORCS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1694-Ab-1/ GM-Tg-hg-MP1694-Ab-2 | Anti-Human SORCS3 monoclonal antibody | Human |
| GM-Tg-rg-MP1694-Ab-1/ GM-Tg-rg-MP1694-Ab-2 | Anti-Rat SORCS3 monoclonal antibody | Rat |
| GM-Tg-mg-MP1694-Ab-1/ GM-Tg-mg-MP1694-Ab-2 | Anti-Mouse SORCS3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1694-Ab-1/ GM-Tg-cynog-MP1694-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SORCS3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1694-Ab-1/ GM-Tg-felg-MP1694-Ab-2 | Anti-Feline SORCS3 monoclonal antibody | Feline |
| GM-Tg-cang-MP1694-Ab-1/ GM-Tg-cang-MP1694-Ab-2 | Anti-Canine SORCS3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1694-Ab-1/ GM-Tg-bovg-MP1694-Ab-2 | Anti-Bovine SORCS3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1694-Ab-1/ GM-Tg-equg-MP1694-Ab-2 | Anti-Equine SORCS3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1694-Ab-1/ GM-Tg-hg-MP1694-Ab-2; GM-Tg-rg-MP1694-Ab-1/ GM-Tg-rg-MP1694-Ab-2; GM-Tg-mg-MP1694-Ab-1/ GM-Tg-mg-MP1694-Ab-2; GM-Tg-cynog-MP1694-Ab-1/ GM-Tg-cynog-MP1694-Ab-2; GM-Tg-felg-MP1694-Ab-1/ GM-Tg-felg-MP1694-Ab-2; GM-Tg-cang-MP1694-Ab-1/ GM-Tg-cang-MP1694-Ab-2; GM-Tg-bovg-MP1694-Ab-1/ GM-Tg-bovg-MP1694-Ab-2; GM-Tg-equg-MP1694-Ab-1/ GM-Tg-equg-MP1694-Ab-2 |
| Products Name | Anti-SORCS3 monoclonal antibody |
| Format | mab |
| Target Name | SORCS3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SORCS3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SORC3/ SORCS3/ SORCS VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1694 |
| Target Name | SORCS3 |
| Gene ID | 22986,66673,294043,693500,486879,101097597,531405,100069497 |
| Gene Symbol and Synonyms | 6330404A12Rik,SORCS,SORCS3 |
| Uniprot Accession | Q9UPU3 |
| Uniprot Entry Name | SORC3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000156395 |
| Target Classification | N/A |
The target: SORCS3, gene name: SORCS3, also named as SORCS. This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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