Anti-SORL/ SORL1/ C11orf32 monoclonal antibody

Anti-SORL/ SORL1/ C11orf32 antibody for FACS & in-vivo assay

Target products collectionGo to SORL1/SORL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1695-Ab-1/ GM-Tg-hg-MP1695-Ab-2Anti-Human SORL1 monoclonal antibodyHuman
GM-Tg-rg-MP1695-Ab-1/ GM-Tg-rg-MP1695-Ab-2Anti-Rat SORL1 monoclonal antibodyRat
GM-Tg-mg-MP1695-Ab-1/ GM-Tg-mg-MP1695-Ab-2Anti-Mouse SORL1 monoclonal antibodyMouse
GM-Tg-cynog-MP1695-Ab-1/ GM-Tg-cynog-MP1695-Ab-2Anti-Cynomolgus/ Rhesus macaque SORL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1695-Ab-1/ GM-Tg-felg-MP1695-Ab-2Anti-Feline SORL1 monoclonal antibodyFeline
GM-Tg-cang-MP1695-Ab-1/ GM-Tg-cang-MP1695-Ab-2Anti-Canine SORL1 monoclonal antibodyCanine
GM-Tg-bovg-MP1695-Ab-1/ GM-Tg-bovg-MP1695-Ab-2Anti-Bovine SORL1 monoclonal antibodyBovine
GM-Tg-equg-MP1695-Ab-1/ GM-Tg-equg-MP1695-Ab-2Anti-Equine SORL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1695-Ab-1/ GM-Tg-hg-MP1695-Ab-2; GM-Tg-rg-MP1695-Ab-1/ GM-Tg-rg-MP1695-Ab-2;
GM-Tg-mg-MP1695-Ab-1/ GM-Tg-mg-MP1695-Ab-2; GM-Tg-cynog-MP1695-Ab-1/ GM-Tg-cynog-MP1695-Ab-2;
GM-Tg-felg-MP1695-Ab-1/ GM-Tg-felg-MP1695-Ab-2; GM-Tg-cang-MP1695-Ab-1/ GM-Tg-cang-MP1695-Ab-2;
GM-Tg-bovg-MP1695-Ab-1/ GM-Tg-bovg-MP1695-Ab-2; GM-Tg-equg-MP1695-Ab-1/ GM-Tg-equg-MP1695-Ab-2
Products NameAnti-SORL1 monoclonal antibody
Formatmab
Target NameSORL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SORL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SORL/ SORL1/ C11orf32 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1695
    Target NameSORL1
    Gene ID6653,20660,300652,713011,479408,101086173,533166,100071572
    Gene Symbol and Synonyms2900010L19Rik,C11orf32,gp250,LR11,LRP9,mSorLA,RGD619914,SORL1,SORLA,SorLA-1
    Uniprot AccessionQ92673,P0DSP1
    Uniprot Entry NameSORL_HUMAN,SORL_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000137642
    Target ClassificationN/A

    The target: SORL1, gene name: SORL1, also named as C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250. This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.