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Anti-SORT/ SORT1/ Gp95 monoclonal antibody
Anti-SORT/ SORT1/ Gp95 antibody for FACS & in-vivo assay
Go to SORT1/SORT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1696-Ab-1/ GM-Tg-hg-MP1696-Ab-2 | Anti-Human SORT1 monoclonal antibody | Human |
| GM-Tg-rg-MP1696-Ab-1/ GM-Tg-rg-MP1696-Ab-2 | Anti-Rat SORT1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1696-Ab-1/ GM-Tg-mg-MP1696-Ab-2 | Anti-Mouse SORT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1696-Ab-1/ GM-Tg-cynog-MP1696-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SORT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1696-Ab-1/ GM-Tg-felg-MP1696-Ab-2 | Anti-Feline SORT1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1696-Ab-1/ GM-Tg-cang-MP1696-Ab-2 | Anti-Canine SORT1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1696-Ab-1/ GM-Tg-bovg-MP1696-Ab-2 | Anti-Bovine SORT1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1696-Ab-1/ GM-Tg-equg-MP1696-Ab-2 | Anti-Equine SORT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1696-Ab-1/ GM-Tg-hg-MP1696-Ab-2; GM-Tg-rg-MP1696-Ab-1/ GM-Tg-rg-MP1696-Ab-2; GM-Tg-mg-MP1696-Ab-1/ GM-Tg-mg-MP1696-Ab-2; GM-Tg-cynog-MP1696-Ab-1/ GM-Tg-cynog-MP1696-Ab-2; GM-Tg-felg-MP1696-Ab-1/ GM-Tg-felg-MP1696-Ab-2; GM-Tg-cang-MP1696-Ab-1/ GM-Tg-cang-MP1696-Ab-2; GM-Tg-bovg-MP1696-Ab-1/ GM-Tg-bovg-MP1696-Ab-2; GM-Tg-equg-MP1696-Ab-1/ GM-Tg-equg-MP1696-Ab-2 |
| Products Name | Anti-SORT1 monoclonal antibody |
| Format | mab |
| Target Name | SORT1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SORT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-298 | Pre-Made Latozinemab biosimilar, Whole mAb, Anti-SORT1 Antibody: Anti-Gp95/LDLCQ6/NT3/NTR3 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species SORT/ SORT1/ Gp95 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1696 |
| Target Name | SORT1 |
| Gene ID | 6272,20661,83576,698310,479915,101090199,511591,100061385 |
| Gene Symbol and Synonyms | 2900053A11Rik,Gp95,LDLCQ6,NT3,NTR3,Nts3,Ntsr3,SORT1 |
| Uniprot Accession | Q99523,O54861 |
| Uniprot Entry Name | SORT_HUMAN,SORT_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000134243 |
| Target Classification | N/A |
The target: SORT1, gene name: SORT1, also named as Gp95, LDLCQ6, NT3, NTR3. This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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