Anti-SPTCS/ SPG11/ ALS5 monoclonal antibody

Anti-SPTCS/ SPG11/ ALS5 antibody for FACS & in-vivo assay

Target products collectionGo to SPG11/SPG11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1698-Ab-1/ GM-Tg-hg-MP1698-Ab-2Anti-Human SPG11 monoclonal antibodyHuman
GM-Tg-rg-MP1698-Ab-1/ GM-Tg-rg-MP1698-Ab-2Anti-Rat SPG11 monoclonal antibodyRat
GM-Tg-mg-MP1698-Ab-1/ GM-Tg-mg-MP1698-Ab-2Anti-Mouse SPG11 monoclonal antibodyMouse
GM-Tg-cynog-MP1698-Ab-1/ GM-Tg-cynog-MP1698-Ab-2Anti-Cynomolgus/ Rhesus macaque SPG11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1698-Ab-1/ GM-Tg-felg-MP1698-Ab-2Anti-Feline SPG11 monoclonal antibodyFeline
GM-Tg-cang-MP1698-Ab-1/ GM-Tg-cang-MP1698-Ab-2Anti-Canine SPG11 monoclonal antibodyCanine
GM-Tg-bovg-MP1698-Ab-1/ GM-Tg-bovg-MP1698-Ab-2Anti-Bovine SPG11 monoclonal antibodyBovine
GM-Tg-equg-MP1698-Ab-1/ GM-Tg-equg-MP1698-Ab-2Anti-Equine SPG11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1698-Ab-1/ GM-Tg-hg-MP1698-Ab-2; GM-Tg-rg-MP1698-Ab-1/ GM-Tg-rg-MP1698-Ab-2;
GM-Tg-mg-MP1698-Ab-1/ GM-Tg-mg-MP1698-Ab-2; GM-Tg-cynog-MP1698-Ab-1/ GM-Tg-cynog-MP1698-Ab-2;
GM-Tg-felg-MP1698-Ab-1/ GM-Tg-felg-MP1698-Ab-2; GM-Tg-cang-MP1698-Ab-1/ GM-Tg-cang-MP1698-Ab-2;
GM-Tg-bovg-MP1698-Ab-1/ GM-Tg-bovg-MP1698-Ab-2; GM-Tg-equg-MP1698-Ab-1/ GM-Tg-equg-MP1698-Ab-2
Products NameAnti-SPG11 monoclonal antibody
Formatmab
Target NameSPG11
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPG11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SPTCS/ SPG11/ ALS5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1698
    Target NameSPG11
    Gene ID80208,214585,311372,712221,100856719,101093692,507819,100070629
    Gene Symbol and Synonyms6030465E24Rik,A330015I11,ALS5,C530005A01Rik,CMT2X,KIAA1840,RGD1562529,SPG11
    Uniprot AccessionQ96JI7
    Uniprot Entry NameSPTCS_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000104133
    Target ClassificationN/A

    The target: SPG11, gene name: SPG11, also named as ALS5, CMT2X, KIAA1840. The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.