Anti-SPNS2 monoclonal antibody

Anti-SPNS2 antibody for FACS & in-vivo assay

Target products collectionGo to SPNS2/SPNS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1701-Ab-1/ GM-Tg-hg-MP1701-Ab-2Anti-Human SPNS2 monoclonal antibodyHuman
GM-Tg-rg-MP1701-Ab-1/ GM-Tg-rg-MP1701-Ab-2Anti-Rat SPNS2 monoclonal antibodyRat
GM-Tg-mg-MP1701-Ab-1/ GM-Tg-mg-MP1701-Ab-2Anti-Mouse SPNS2 monoclonal antibodyMouse
GM-Tg-cynog-MP1701-Ab-1/ GM-Tg-cynog-MP1701-Ab-2Anti-Cynomolgus/ Rhesus macaque SPNS2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1701-Ab-1/ GM-Tg-felg-MP1701-Ab-2Anti-Feline SPNS2 monoclonal antibodyFeline
GM-Tg-cang-MP1701-Ab-1/ GM-Tg-cang-MP1701-Ab-2Anti-Canine SPNS2 monoclonal antibodyCanine
GM-Tg-bovg-MP1701-Ab-1/ GM-Tg-bovg-MP1701-Ab-2Anti-Bovine SPNS2 monoclonal antibodyBovine
GM-Tg-equg-MP1701-Ab-1/ GM-Tg-equg-MP1701-Ab-2Anti-Equine SPNS2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1701-Ab-1/ GM-Tg-hg-MP1701-Ab-2; GM-Tg-rg-MP1701-Ab-1/ GM-Tg-rg-MP1701-Ab-2;
GM-Tg-mg-MP1701-Ab-1/ GM-Tg-mg-MP1701-Ab-2; GM-Tg-cynog-MP1701-Ab-1/ GM-Tg-cynog-MP1701-Ab-2;
GM-Tg-felg-MP1701-Ab-1/ GM-Tg-felg-MP1701-Ab-2; GM-Tg-cang-MP1701-Ab-1/ GM-Tg-cang-MP1701-Ab-2;
GM-Tg-bovg-MP1701-Ab-1/ GM-Tg-bovg-MP1701-Ab-2; GM-Tg-equg-MP1701-Ab-1/ GM-Tg-equg-MP1701-Ab-2
Products NameAnti-SPNS2 monoclonal antibody
Formatmab
Target NameSPNS2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPNS2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SPNS2 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1701
    Target NameSPNS2
    Gene ID124976,216892,100270678,721549,606858,109494079,613889,100072726
    Gene Symbol and SynonymsDFNB115,SLC62A2,SLC63A2,SPNS2
    Uniprot AccessionQ8IVW8
    Uniprot Entry NameSPNS2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000183018
    Target ClassificationN/A

    The target: SPNS2, gene name: SPNS2, also named as . The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.