Anti-SPP2A/ SPPL2A/ IMP3 monoclonal antibody

Anti-SPP2A/ SPPL2A/ IMP3 antibody for FACS & in-vivo assay

Target products collectionGo to SPPL2A/SPPL2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1702-Ab-1/ GM-Tg-hg-MP1702-Ab-2Anti-Human SPPL2A monoclonal antibodyHuman
GM-Tg-rg-MP1702-Ab-1/ GM-Tg-rg-MP1702-Ab-2Anti-Rat SPPL2A monoclonal antibodyRat
GM-Tg-mg-MP1702-Ab-1/ GM-Tg-mg-MP1702-Ab-2Anti-Mouse SPPL2A monoclonal antibodyMouse
GM-Tg-cynog-MP1702-Ab-1/ GM-Tg-cynog-MP1702-Ab-2Anti-Cynomolgus/ Rhesus macaque SPPL2A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1702-Ab-1/ GM-Tg-felg-MP1702-Ab-2Anti-Feline SPPL2A monoclonal antibodyFeline
GM-Tg-cang-MP1702-Ab-1/ GM-Tg-cang-MP1702-Ab-2Anti-Canine SPPL2A monoclonal antibodyCanine
GM-Tg-bovg-MP1702-Ab-1/ GM-Tg-bovg-MP1702-Ab-2Anti-Bovine SPPL2A monoclonal antibodyBovine
GM-Tg-equg-MP1702-Ab-1/ GM-Tg-equg-MP1702-Ab-2Anti-Equine SPPL2A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1702-Ab-1/ GM-Tg-hg-MP1702-Ab-2; GM-Tg-rg-MP1702-Ab-1/ GM-Tg-rg-MP1702-Ab-2;
GM-Tg-mg-MP1702-Ab-1/ GM-Tg-mg-MP1702-Ab-2; GM-Tg-cynog-MP1702-Ab-1/ GM-Tg-cynog-MP1702-Ab-2;
GM-Tg-felg-MP1702-Ab-1/ GM-Tg-felg-MP1702-Ab-2; GM-Tg-cang-MP1702-Ab-1/ GM-Tg-cang-MP1702-Ab-2;
GM-Tg-bovg-MP1702-Ab-1/ GM-Tg-bovg-MP1702-Ab-2; GM-Tg-equg-MP1702-Ab-1/ GM-Tg-equg-MP1702-Ab-2
Products NameAnti-SPPL2A monoclonal antibody
Formatmab
Target NameSPPL2A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SPPL2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SPP2A/ SPPL2A/ IMP3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1702
    Target NameSPPL2A
    Gene ID84888,66552,311401,693365,478301,101083341,530325,100069832
    Gene Symbol and Synonyms2010106G01Rik,C130089K23Rik,IMD86,IMP3,PSL2,RGD1563001,SPPL2A
    Uniprot AccessionQ8TCT8
    Uniprot Entry NameSPP2A_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000138600
    Target ClassificationN/A

    The target: SPPL2A, gene name: SPPL2A, also named as IMP3, PSL2. This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.