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Anti-SPP2B/ SPPL2B/ IMP-4 monoclonal antibody
Anti-SPP2B/ SPPL2B/ IMP-4 antibody for FACS & in-vivo assay
Go to SPPL2B/SPPL2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1703-Ab-1/ GM-Tg-hg-MP1703-Ab-2 | Anti-Human SPPL2B monoclonal antibody | Human |
| GM-Tg-rg-MP1703-Ab-1/ GM-Tg-rg-MP1703-Ab-2 | Anti-Rat SPPL2B monoclonal antibody | Rat |
| GM-Tg-mg-MP1703-Ab-1/ GM-Tg-mg-MP1703-Ab-2 | Anti-Mouse SPPL2B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1703-Ab-1/ GM-Tg-cynog-MP1703-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPPL2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1703-Ab-1/ GM-Tg-felg-MP1703-Ab-2 | Anti-Feline SPPL2B monoclonal antibody | Feline |
| GM-Tg-cang-MP1703-Ab-1/ GM-Tg-cang-MP1703-Ab-2 | Anti-Canine SPPL2B monoclonal antibody | Canine |
| GM-Tg-bovg-MP1703-Ab-1/ GM-Tg-bovg-MP1703-Ab-2 | Anti-Bovine SPPL2B monoclonal antibody | Bovine |
| GM-Tg-equg-MP1703-Ab-1/ GM-Tg-equg-MP1703-Ab-2 | Anti-Equine SPPL2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1703-Ab-1/ GM-Tg-hg-MP1703-Ab-2; GM-Tg-rg-MP1703-Ab-1/ GM-Tg-rg-MP1703-Ab-2; GM-Tg-mg-MP1703-Ab-1/ GM-Tg-mg-MP1703-Ab-2; GM-Tg-cynog-MP1703-Ab-1/ GM-Tg-cynog-MP1703-Ab-2; GM-Tg-felg-MP1703-Ab-1/ GM-Tg-felg-MP1703-Ab-2; GM-Tg-cang-MP1703-Ab-1/ GM-Tg-cang-MP1703-Ab-2; GM-Tg-bovg-MP1703-Ab-1/ GM-Tg-bovg-MP1703-Ab-2; GM-Tg-equg-MP1703-Ab-1/ GM-Tg-equg-MP1703-Ab-2 |
| Products Name | Anti-SPPL2B monoclonal antibody |
| Format | mab |
| Target Name | SPPL2B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SPPL2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SPP2B/ SPPL2B/ IMP-4 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1703 |
| Target Name | SPPL2B |
| Gene ID | 56928,73218,362828,710493,485071,101081277,504285,100060546 |
| Gene Symbol and Synonyms | 3110056O03Rik,IMP-4,IMP4,PSH4,PSL1,RGD1308556,SPPL2B |
| Uniprot Accession | Q8TCT7,Q5PQL3 |
| Uniprot Entry Name | SPP2B_HUMAN,SPP2B_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000005206 |
| Target Classification | N/A |
The target: SPPL2B, gene name: SPPL2B, also named as IMP-4, IMP4, PSH4, PSL1. This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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