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Anti-STEA4/ STEAP4/ STAMP2 monoclonal antibody
Anti-STEA4/ STEAP4/ STAMP2 antibody for FACS & in-vivo assay
Go to STEAP4/STEAP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1715-Ab-1/ GM-Tg-hg-MP1715-Ab-2 | Anti-Human STEAP4 monoclonal antibody | Human |
| GM-Tg-rg-MP1715-Ab-1/ GM-Tg-rg-MP1715-Ab-2 | Anti-Rat STEAP4 monoclonal antibody | Rat |
| GM-Tg-mg-MP1715-Ab-1/ GM-Tg-mg-MP1715-Ab-2 | Anti-Mouse STEAP4 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1715-Ab-1/ GM-Tg-cynog-MP1715-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STEAP4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1715-Ab-1/ GM-Tg-felg-MP1715-Ab-2 | Anti-Feline STEAP4 monoclonal antibody | Feline |
| GM-Tg-cang-MP1715-Ab-1/ GM-Tg-cang-MP1715-Ab-2 | Anti-Canine STEAP4 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1715-Ab-1/ GM-Tg-bovg-MP1715-Ab-2 | Anti-Bovine STEAP4 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1715-Ab-1/ GM-Tg-equg-MP1715-Ab-2 | Anti-Equine STEAP4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1715-Ab-1/ GM-Tg-hg-MP1715-Ab-2; GM-Tg-rg-MP1715-Ab-1/ GM-Tg-rg-MP1715-Ab-2; GM-Tg-mg-MP1715-Ab-1/ GM-Tg-mg-MP1715-Ab-2; GM-Tg-cynog-MP1715-Ab-1/ GM-Tg-cynog-MP1715-Ab-2; GM-Tg-felg-MP1715-Ab-1/ GM-Tg-felg-MP1715-Ab-2; GM-Tg-cang-MP1715-Ab-1/ GM-Tg-cang-MP1715-Ab-2; GM-Tg-bovg-MP1715-Ab-1/ GM-Tg-bovg-MP1715-Ab-2; GM-Tg-equg-MP1715-Ab-1/ GM-Tg-equg-MP1715-Ab-2 |
| Products Name | Anti-STEAP4 monoclonal antibody |
| Format | mab |
| Target Name | STEAP4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-STEAP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species STEA4/ STEAP4/ STAMP2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001581 | human STEAP4 Lentivirus particle |
| ORF Viral Vector | pGMLP001581 | human STEAP4 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000369 | Norway rat Steap4 AAV plasmid |
| ORF Viral Vector | pGMLPm001788 | mouse Steap4 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000369 | Norway rat Steap4 AAV particle |
| ORF Viral Vector | vGMLPm001788 | mouse Steap4 Lentivirus particle |
Target information
| Target ID | GM-MP1715 |
| Target Name | STEAP4 |
| Gene ID | 79689,117167,705096,119876970,101101204,538861,100059718 |
| Gene Symbol and Synonyms | 1110021O17Rik,LOC119876970,SchLAH,STAMP2,STEAP4,TIARP,TNFAIP9 |
| Uniprot Accession | Q687X5 |
| Uniprot Entry Name | STEA4_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000127954 |
| Target Classification | N/A |
The target: STEAP4, gene name: STEAP4, also named as STAMP2, SchLAH, TIARP, TNFAIP9. The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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