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Anti-STX1A/ HPC-1/ P35-1 monoclonal antibody
Anti-STX1A/ HPC-1/ P35-1 antibody for FACS & in-vivo assay
Go to STX1A/STX1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1724-Ab-1/ GM-Tg-hg-MP1724-Ab-2 | Anti-Human STX1A monoclonal antibody | Human |
| GM-Tg-rg-MP1724-Ab-1/ GM-Tg-rg-MP1724-Ab-2 | Anti-Rat STX1A monoclonal antibody | Rat |
| GM-Tg-mg-MP1724-Ab-1/ GM-Tg-mg-MP1724-Ab-2 | Anti-Mouse STX1A monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1724-Ab-1/ GM-Tg-cynog-MP1724-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STX1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1724-Ab-1/ GM-Tg-felg-MP1724-Ab-2 | Anti-Feline STX1A monoclonal antibody | Feline |
| GM-Tg-cang-MP1724-Ab-1/ GM-Tg-cang-MP1724-Ab-2 | Anti-Canine STX1A monoclonal antibody | Canine |
| GM-Tg-bovg-MP1724-Ab-1/ GM-Tg-bovg-MP1724-Ab-2 | Anti-Bovine STX1A monoclonal antibody | Bovine |
| GM-Tg-equg-MP1724-Ab-1/ GM-Tg-equg-MP1724-Ab-2 | Anti-Equine STX1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1724-Ab-1/ GM-Tg-hg-MP1724-Ab-2; GM-Tg-rg-MP1724-Ab-1/ GM-Tg-rg-MP1724-Ab-2; GM-Tg-mg-MP1724-Ab-1/ GM-Tg-mg-MP1724-Ab-2; GM-Tg-cynog-MP1724-Ab-1/ GM-Tg-cynog-MP1724-Ab-2; GM-Tg-felg-MP1724-Ab-1/ GM-Tg-felg-MP1724-Ab-2; GM-Tg-cang-MP1724-Ab-1/ GM-Tg-cang-MP1724-Ab-2; GM-Tg-bovg-MP1724-Ab-1/ GM-Tg-bovg-MP1724-Ab-2; GM-Tg-equg-MP1724-Ab-1/ GM-Tg-equg-MP1724-Ab-2 |
| Products Name | Anti-STX1A monoclonal antibody |
| Format | mab |
| Target Name | STX1A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-STX1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species STX1A/ HPC-1/ P35-1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002902 | human STX1A Lentivirus particle |
| ORF Viral Vector | pGMLP002902 | human STX1A Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002599 | mouse Stx1a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002599 | mouse Stx1a Lentivirus particle |
Target information
| Target ID | GM-MP1724 |
| Target Name | STX1A |
| Gene ID | 6804,20907,116470,574205,100855965,101097118,788566,100061863 |
| Gene Symbol and Synonyms | HPC-1,P35-1,STX1,STX1A,STX1B2,SYN1A |
| Uniprot Accession | Q16623,P32851,P32850 |
| Uniprot Entry Name | STX1A_HUMAN,STX1A_RAT,STX1A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000106089 |
| Target Classification | N/A |
The target: STX1A, gene name: STX1A, also named as HPC-1, P35-1, STX1, SYN1A. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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