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Anti-SV2B/ HsT19680 monoclonal antibody
Anti-SV2B/ HsT19680 antibody for FACS & in-vivo assay
Go to SV2B/SV2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1735-Ab-1/ GM-Tg-hg-MP1735-Ab-2 | Anti-Human SV2B monoclonal antibody | Human |
| GM-Tg-rg-MP1735-Ab-1/ GM-Tg-rg-MP1735-Ab-2 | Anti-Rat SV2B monoclonal antibody | Rat |
| GM-Tg-mg-MP1735-Ab-1/ GM-Tg-mg-MP1735-Ab-2 | Anti-Mouse SV2B monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1735-Ab-1/ GM-Tg-cynog-MP1735-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SV2B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1735-Ab-1/ GM-Tg-felg-MP1735-Ab-2 | Anti-Feline SV2B monoclonal antibody | Feline |
| GM-Tg-cang-MP1735-Ab-1/ GM-Tg-cang-MP1735-Ab-2 | Anti-Canine SV2B monoclonal antibody | Canine |
| GM-Tg-bovg-MP1735-Ab-1/ GM-Tg-bovg-MP1735-Ab-2 | Anti-Bovine SV2B monoclonal antibody | Bovine |
| GM-Tg-equg-MP1735-Ab-1/ GM-Tg-equg-MP1735-Ab-2 | Anti-Equine SV2B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1735-Ab-1/ GM-Tg-hg-MP1735-Ab-2; GM-Tg-rg-MP1735-Ab-1/ GM-Tg-rg-MP1735-Ab-2; GM-Tg-mg-MP1735-Ab-1/ GM-Tg-mg-MP1735-Ab-2; GM-Tg-cynog-MP1735-Ab-1/ GM-Tg-cynog-MP1735-Ab-2; GM-Tg-felg-MP1735-Ab-1/ GM-Tg-felg-MP1735-Ab-2; GM-Tg-cang-MP1735-Ab-1/ GM-Tg-cang-MP1735-Ab-2; GM-Tg-bovg-MP1735-Ab-1/ GM-Tg-bovg-MP1735-Ab-2; GM-Tg-equg-MP1735-Ab-1/ GM-Tg-equg-MP1735-Ab-2 |
| Products Name | Anti-SV2B monoclonal antibody |
| Format | mab |
| Target Name | SV2B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SV2B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SV2B/ HsT19680 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1735 |
| Target Name | SV2B |
| Gene ID | 9899,64176,117556,710980,488723,101093273,527014,100070267 |
| Gene Symbol and Synonyms | A830038F04Rik,HsT19680,mKIAA0735,SLC22B2,SV2B |
| Uniprot Accession | Q7L1I2,Q63564 |
| Uniprot Entry Name | SV2B_HUMAN,SV2B_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000185518 |
| Target Classification | N/A |
The target: SV2B, gene name: SV2B, also named as HsT19680. This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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