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Anti-SYT12/ SYT11/ sytXII monoclonal antibody
Anti-SYT12/ SYT11/ sytXII antibody for FACS & in-vivo assay
Go to SYT12/SYT12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1741-Ab-1/ GM-Tg-hg-MP1741-Ab-2 | Anti-Human SYT12 monoclonal antibody | Human |
| GM-Tg-rg-MP1741-Ab-1/ GM-Tg-rg-MP1741-Ab-2 | Anti-Rat SYT12 monoclonal antibody | Rat |
| GM-Tg-mg-MP1741-Ab-1/ GM-Tg-mg-MP1741-Ab-2 | Anti-Mouse SYT12 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1741-Ab-1/ GM-Tg-cynog-MP1741-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SYT12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1741-Ab-1/ GM-Tg-felg-MP1741-Ab-2 | Anti-Feline SYT12 monoclonal antibody | Feline |
| GM-Tg-cang-MP1741-Ab-1/ GM-Tg-cang-MP1741-Ab-2 | Anti-Canine SYT12 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1741-Ab-1/ GM-Tg-bovg-MP1741-Ab-2 | Anti-Bovine SYT12 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1741-Ab-1/ GM-Tg-equg-MP1741-Ab-2 | Anti-Equine SYT12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1741-Ab-1/ GM-Tg-hg-MP1741-Ab-2; GM-Tg-rg-MP1741-Ab-1/ GM-Tg-rg-MP1741-Ab-2; GM-Tg-mg-MP1741-Ab-1/ GM-Tg-mg-MP1741-Ab-2; GM-Tg-cynog-MP1741-Ab-1/ GM-Tg-cynog-MP1741-Ab-2; GM-Tg-felg-MP1741-Ab-1/ GM-Tg-felg-MP1741-Ab-2; GM-Tg-cang-MP1741-Ab-1/ GM-Tg-cang-MP1741-Ab-2; GM-Tg-bovg-MP1741-Ab-1/ GM-Tg-bovg-MP1741-Ab-2; GM-Tg-equg-MP1741-Ab-1/ GM-Tg-equg-MP1741-Ab-2 |
| Products Name | Anti-SYT12 monoclonal antibody |
| Format | mab |
| Target Name | SYT12 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SYT12 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SYT12/ SYT11/ sytXII VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003127 | human SYT12 Lentivirus particle |
| ORF Viral Vector | pGMLP003127 | human SYT12 Lentivirus plasmid |
Target information
| Target ID | GM-MP1741 |
| Target Name | SYT12 |
| Gene ID | 91683,171180,191595,721773,483703,101090292,536820,100052905 |
| Gene Symbol and Synonyms | Srg1,SYT11,SYT12,sytXII |
| Uniprot Accession | Q8IV01,P97610 |
| Uniprot Entry Name | SYT12_HUMAN,SYT12_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000173227 |
| Target Classification | N/A |
The target: SYT12, gene name: SYT12, also named as SYT11, sytXII. This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
