Anti-SYT5 monoclonal antibody

Anti-SYT5 antibody for FACS & in-vivo assay

Target products collectionGo to SYT5/SYT5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1747-Ab-1/ GM-Tg-hg-MP1747-Ab-2Anti-Human SYT5 monoclonal antibodyHuman
GM-Tg-rg-MP1747-Ab-1/ GM-Tg-rg-MP1747-Ab-2Anti-Rat SYT5 monoclonal antibodyRat
GM-Tg-mg-MP1747-Ab-1/ GM-Tg-mg-MP1747-Ab-2Anti-Mouse SYT5 monoclonal antibodyMouse
GM-Tg-cynog-MP1747-Ab-1/ GM-Tg-cynog-MP1747-Ab-2Anti-Cynomolgus/ Rhesus macaque SYT5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1747-Ab-1/ GM-Tg-felg-MP1747-Ab-2Anti-Feline SYT5 monoclonal antibodyFeline
GM-Tg-cang-MP1747-Ab-1/ GM-Tg-cang-MP1747-Ab-2Anti-Canine SYT5 monoclonal antibodyCanine
GM-Tg-bovg-MP1747-Ab-1/ GM-Tg-bovg-MP1747-Ab-2Anti-Bovine SYT5 monoclonal antibodyBovine
GM-Tg-equg-MP1747-Ab-1/ GM-Tg-equg-MP1747-Ab-2Anti-Equine SYT5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1747-Ab-1/ GM-Tg-hg-MP1747-Ab-2; GM-Tg-rg-MP1747-Ab-1/ GM-Tg-rg-MP1747-Ab-2;
GM-Tg-mg-MP1747-Ab-1/ GM-Tg-mg-MP1747-Ab-2; GM-Tg-cynog-MP1747-Ab-1/ GM-Tg-cynog-MP1747-Ab-2;
GM-Tg-felg-MP1747-Ab-1/ GM-Tg-felg-MP1747-Ab-2; GM-Tg-cang-MP1747-Ab-1/ GM-Tg-cang-MP1747-Ab-2;
GM-Tg-bovg-MP1747-Ab-1/ GM-Tg-bovg-MP1747-Ab-2; GM-Tg-equg-MP1747-Ab-1/ GM-Tg-equg-MP1747-Ab-2
Products NameAnti-SYT5 monoclonal antibody
Formatmab
Target NameSYT5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SYT5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SYT5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1747
    Target NameSYT5
    Gene ID6861,53420,54309,106994863,476382,101086106,539616,100050341
    Gene Symbol and SynonymsSYT5,SytIX,SytV
    Uniprot AccessionO00445,P47861
    Uniprot Entry NameSYT5_HUMAN,SYT5_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000129990
    Target ClassificationN/A

    The target: SYT5, gene name: SYT5, also named as . Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.