Anti-SYT8 monoclonal antibody

Anti-SYT8 antibody for FACS & in-vivo assay

Target products collectionGo to SYT8/SYT8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1750-Ab-1/ GM-Tg-hg-MP1750-Ab-2Anti-Human SYT8 monoclonal antibodyHuman
GM-Tg-rg-MP1750-Ab-1/ GM-Tg-rg-MP1750-Ab-2Anti-Rat SYT8 monoclonal antibodyRat
GM-Tg-mg-MP1750-Ab-1/ GM-Tg-mg-MP1750-Ab-2Anti-Mouse SYT8 monoclonal antibodyMouse
GM-Tg-cynog-MP1750-Ab-1/ GM-Tg-cynog-MP1750-Ab-2Anti-Cynomolgus/ Rhesus macaque SYT8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1750-Ab-1/ GM-Tg-felg-MP1750-Ab-2Anti-Feline SYT8 monoclonal antibodyFeline
GM-Tg-cang-MP1750-Ab-1/ GM-Tg-cang-MP1750-Ab-2Anti-Canine SYT8 monoclonal antibodyCanine
GM-Tg-bovg-MP1750-Ab-1/ GM-Tg-bovg-MP1750-Ab-2Anti-Bovine SYT8 monoclonal antibodyBovine
GM-Tg-equg-MP1750-Ab-1/ GM-Tg-equg-MP1750-Ab-2Anti-Equine SYT8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1750-Ab-1/ GM-Tg-hg-MP1750-Ab-2; GM-Tg-rg-MP1750-Ab-1/ GM-Tg-rg-MP1750-Ab-2;
GM-Tg-mg-MP1750-Ab-1/ GM-Tg-mg-MP1750-Ab-2; GM-Tg-cynog-MP1750-Ab-1/ GM-Tg-cynog-MP1750-Ab-2;
GM-Tg-felg-MP1750-Ab-1/ GM-Tg-felg-MP1750-Ab-2; GM-Tg-cang-MP1750-Ab-1/ GM-Tg-cang-MP1750-Ab-2;
GM-Tg-bovg-MP1750-Ab-1/ GM-Tg-bovg-MP1750-Ab-2; GM-Tg-equg-MP1750-Ab-1/ GM-Tg-equg-MP1750-Ab-2
Products NameAnti-SYT8 monoclonal antibody
Formatmab
Target NameSYT8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SYT8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SYT8 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1750
    Target NameSYT8
    Gene ID90019,55925,60566,721025,611547,101094375,613562,100060863
    Gene Symbol and SynonymsSYT8
    Uniprot AccessionQ8NBV8,Q925B4
    Uniprot Entry NameSYT8_HUMAN,SYT8_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000149043
    Target ClassificationN/A

    The target: SYT8, gene name: SYT8, also named as . This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.