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Anti-T2R38/ TAS2R38/ PTC monoclonal antibody
Anti-T2R38/ TAS2R38/ PTC antibody for FACS & in-vivo assay
Go to TAS2R38/TAS2R38 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1768-Ab-1/ GM-Tg-hg-MP1768-Ab-2 | Anti-Human TAS2R38 monoclonal antibody | Human |
| GM-Tg-rg-MP1768-Ab-1/ GM-Tg-rg-MP1768-Ab-2 | Anti-Rat TAS2R38 monoclonal antibody | Rat |
| GM-Tg-mg-MP1768-Ab-1/ GM-Tg-mg-MP1768-Ab-2 | Anti-Mouse TAS2R38 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1768-Ab-1/ GM-Tg-cynog-MP1768-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TAS2R38 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1768-Ab-1/ GM-Tg-felg-MP1768-Ab-2 | Anti-Feline TAS2R38 monoclonal antibody | Feline |
| GM-Tg-cang-MP1768-Ab-1/ GM-Tg-cang-MP1768-Ab-2 | Anti-Canine TAS2R38 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1768-Ab-1/ GM-Tg-bovg-MP1768-Ab-2 | Anti-Bovine TAS2R38 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1768-Ab-1/ GM-Tg-equg-MP1768-Ab-2 | Anti-Equine TAS2R38 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1768-Ab-1/ GM-Tg-hg-MP1768-Ab-2; GM-Tg-rg-MP1768-Ab-1/ GM-Tg-rg-MP1768-Ab-2; GM-Tg-mg-MP1768-Ab-1/ GM-Tg-mg-MP1768-Ab-2; GM-Tg-cynog-MP1768-Ab-1/ GM-Tg-cynog-MP1768-Ab-2; GM-Tg-felg-MP1768-Ab-1/ GM-Tg-felg-MP1768-Ab-2; GM-Tg-cang-MP1768-Ab-1/ GM-Tg-cang-MP1768-Ab-2; GM-Tg-bovg-MP1768-Ab-1/ GM-Tg-bovg-MP1768-Ab-2; GM-Tg-equg-MP1768-Ab-1/ GM-Tg-equg-MP1768-Ab-2 |
| Products Name | Anti-TAS2R38 monoclonal antibody |
| Format | mab |
| Target Name | TAS2R38 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TAS2R38 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species T2R38/ TAS2R38/ PTC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002876 | human TAS2R38 Lentivirus particle |
| ORF Viral Vector | pGMLP002876 | human TAS2R38 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004008 | mouse Tas2r138 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004008 | mouse Tas2r138 Lentivirus particle |
Target information
| Target ID | GM-MP1768 |
| Target Name | TAS2R38 |
| Gene ID | 5726,387513,500091,695549,100271737,101084695,787789,106783090 |
| Gene Symbol and Synonyms | CAFA-T2R38,Mamu-T2R38,mt2r31,PTC,T2R138,T2R38,T2R61,Tas2r138,TAS2R38,THIOT |
| Uniprot Accession | P59533,Q4VHE7 |
| Uniprot Entry Name | T2R38_HUMAN,T2R38_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000257138 |
| Target Classification | N/A |
The target: TAS2R38, gene name: TAS2R38, also named as PTC, T2R38, T2R61, THIOT. This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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