Anti-TECTA/ DFNA12/ DFNA8 monoclonal antibody

Anti-TECTA/ DFNA12/ DFNA8 antibody for FACS & in-vivo assay

Target products collectionGo to TECTA/TECTA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1785-Ab-1/ GM-Tg-hg-MP1785-Ab-2Anti-Human TECTA monoclonal antibodyHuman
GM-Tg-rg-MP1785-Ab-1/ GM-Tg-rg-MP1785-Ab-2Anti-Rat TECTA monoclonal antibodyRat
GM-Tg-mg-MP1785-Ab-1/ GM-Tg-mg-MP1785-Ab-2Anti-Mouse TECTA monoclonal antibodyMouse
GM-Tg-cynog-MP1785-Ab-1/ GM-Tg-cynog-MP1785-Ab-2Anti-Cynomolgus/ Rhesus macaque TECTA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1785-Ab-1/ GM-Tg-felg-MP1785-Ab-2Anti-Feline TECTA monoclonal antibodyFeline
GM-Tg-cang-MP1785-Ab-1/ GM-Tg-cang-MP1785-Ab-2Anti-Canine TECTA monoclonal antibodyCanine
GM-Tg-bovg-MP1785-Ab-1/ GM-Tg-bovg-MP1785-Ab-2Anti-Bovine TECTA monoclonal antibodyBovine
GM-Tg-equg-MP1785-Ab-1/ GM-Tg-equg-MP1785-Ab-2Anti-Equine TECTA monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1785-Ab-1/ GM-Tg-hg-MP1785-Ab-2; GM-Tg-rg-MP1785-Ab-1/ GM-Tg-rg-MP1785-Ab-2;
GM-Tg-mg-MP1785-Ab-1/ GM-Tg-mg-MP1785-Ab-2; GM-Tg-cynog-MP1785-Ab-1/ GM-Tg-cynog-MP1785-Ab-2;
GM-Tg-felg-MP1785-Ab-1/ GM-Tg-felg-MP1785-Ab-2; GM-Tg-cang-MP1785-Ab-1/ GM-Tg-cang-MP1785-Ab-2;
GM-Tg-bovg-MP1785-Ab-1/ GM-Tg-bovg-MP1785-Ab-2; GM-Tg-equg-MP1785-Ab-1/ GM-Tg-equg-MP1785-Ab-2
Products NameAnti-TECTA monoclonal antibody
Formatmab
Target NameTECTA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TECTA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TECTA/ DFNA12/ DFNA8 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1785
    Target NameTECTA
    Gene ID7007,21683,300653,712586,533133,100063512
    Gene Symbol and SynonymsDFNA12,DFNA8,DFNB21,Tctna,TECTA
    Uniprot AccessionO75443
    Uniprot Entry NameTECTA_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000109927
    Target ClassificationN/A

    The target: TECTA, gene name: TECTA, also named as DFNA12, DFNA8, DFNB21. The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane.  Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.