Anti-TEN4/ TENM4/ Doc4 monoclonal antibody

Anti-TEN4/ TENM4/ Doc4 antibody for FACS & in-vivo assay

Target products collectionGo to TENM4/TENM4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1790-Ab-1/ GM-Tg-hg-MP1790-Ab-2Anti-Human TENM4 monoclonal antibodyHuman
GM-Tg-rg-MP1790-Ab-1/ GM-Tg-rg-MP1790-Ab-2Anti-Rat TENM4 monoclonal antibodyRat
GM-Tg-mg-MP1790-Ab-1/ GM-Tg-mg-MP1790-Ab-2Anti-Mouse TENM4 monoclonal antibodyMouse
GM-Tg-cynog-MP1790-Ab-1/ GM-Tg-cynog-MP1790-Ab-2Anti-Cynomolgus/ Rhesus macaque TENM4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1790-Ab-1/ GM-Tg-felg-MP1790-Ab-2Anti-Feline TENM4 monoclonal antibodyFeline
GM-Tg-cang-MP1790-Ab-1/ GM-Tg-cang-MP1790-Ab-2Anti-Canine TENM4 monoclonal antibodyCanine
GM-Tg-bovg-MP1790-Ab-1/ GM-Tg-bovg-MP1790-Ab-2Anti-Bovine TENM4 monoclonal antibodyBovine
GM-Tg-equg-MP1790-Ab-1/ GM-Tg-equg-MP1790-Ab-2Anti-Equine TENM4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1790-Ab-1/ GM-Tg-hg-MP1790-Ab-2; GM-Tg-rg-MP1790-Ab-1/ GM-Tg-rg-MP1790-Ab-2;
GM-Tg-mg-MP1790-Ab-1/ GM-Tg-mg-MP1790-Ab-2; GM-Tg-cynog-MP1790-Ab-1/ GM-Tg-cynog-MP1790-Ab-2;
GM-Tg-felg-MP1790-Ab-1/ GM-Tg-felg-MP1790-Ab-2; GM-Tg-cang-MP1790-Ab-1/ GM-Tg-cang-MP1790-Ab-2;
GM-Tg-bovg-MP1790-Ab-1/ GM-Tg-bovg-MP1790-Ab-2; GM-Tg-equg-MP1790-Ab-1/ GM-Tg-equg-MP1790-Ab-2
Products NameAnti-TENM4 monoclonal antibody
Formatmab
Target NameTENM4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TENM4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TEN4/ TENM4/ Doc4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1790
    Target NameTENM4
    Gene ID26011,23966,308831,701138,485166,101085744,509726,100062728
    Gene Symbol and SynonymsDoc4,ELM2,E™5,l(7)-3Rn,l7Rn3,mKIAA1302,ODZ4,ten-4,Ten-M4,TEN4,TENM4,TNM4
    Uniprot AccessionQ6N022
    Uniprot Entry NameTEN4_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000149256
    Target ClassificationN/A

    The target: TENM4, gene name: TENM4, also named as Doc4, E™5, ODZ4, TNM4, Ten-M4, ten-4. The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.