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Anti-TFR2/ HFE3/ TFRC2 monoclonal antibody
Anti-TFR2/ HFE3/ TFRC2 antibody for FACS & in-vivo assay
Go to TFR2/TFR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1792-Ab-1/ GM-Tg-hg-MP1792-Ab-2 | Anti-Human TFR2 monoclonal antibody | Human |
| GM-Tg-rg-MP1792-Ab-1/ GM-Tg-rg-MP1792-Ab-2 | Anti-Rat TFR2 monoclonal antibody | Rat |
| GM-Tg-mg-MP1792-Ab-1/ GM-Tg-mg-MP1792-Ab-2 | Anti-Mouse TFR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1792-Ab-1/ GM-Tg-cynog-MP1792-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TFR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1792-Ab-1/ GM-Tg-felg-MP1792-Ab-2 | Anti-Feline TFR2 monoclonal antibody | Feline |
| GM-Tg-cang-MP1792-Ab-1/ GM-Tg-cang-MP1792-Ab-2 | Anti-Canine TFR2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1792-Ab-1/ GM-Tg-bovg-MP1792-Ab-2 | Anti-Bovine TFR2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1792-Ab-1/ GM-Tg-equg-MP1792-Ab-2 | Anti-Equine TFR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1792-Ab-1/ GM-Tg-hg-MP1792-Ab-2; GM-Tg-rg-MP1792-Ab-1/ GM-Tg-rg-MP1792-Ab-2; GM-Tg-mg-MP1792-Ab-1/ GM-Tg-mg-MP1792-Ab-2; GM-Tg-cynog-MP1792-Ab-1/ GM-Tg-cynog-MP1792-Ab-2; GM-Tg-felg-MP1792-Ab-1/ GM-Tg-felg-MP1792-Ab-2; GM-Tg-cang-MP1792-Ab-1/ GM-Tg-cang-MP1792-Ab-2; GM-Tg-bovg-MP1792-Ab-1/ GM-Tg-bovg-MP1792-Ab-2; GM-Tg-equg-MP1792-Ab-1/ GM-Tg-equg-MP1792-Ab-2 |
| Products Name | Anti-TFR2 monoclonal antibody |
| Format | mab |
| Target Name | TFR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TFR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TFR2/ HFE3/ TFRC2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001745 | human TFR2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001745 | human TFR2 Lentivirus particle |
Target information
| Target ID | GM-MP1792 |
| Target Name | TFR2 |
| Gene ID | 7036,50765,288562,719240,489834,101092657,617916,100067467 |
| Gene Symbol and Synonyms | HFE3,TFR2,TFRC2,Trfr2 |
| Uniprot Accession | Q9UP52,B2GUY2 |
| Uniprot Entry Name | TFR2_HUMAN,TFR2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000106327 |
| Target Classification | N/A |
The target: TFR2, gene name: TFR2, also named as HFE3, TFRC2. This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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