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Anti-BGH3/ TGFBI/ BIGH3 monoclonal antibody
Anti-BGH3/ TGFBI/ BIGH3 antibody for FACS & in-vivo assay
Go to TGFBI/TGFBI products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1793-Ab-1/ GM-Tg-hg-MP1793-Ab-2 | Anti-Human TGFBI monoclonal antibody | Human |
| GM-Tg-rg-MP1793-Ab-1/ GM-Tg-rg-MP1793-Ab-2 | Anti-Rat TGFBI monoclonal antibody | Rat |
| GM-Tg-mg-MP1793-Ab-1/ GM-Tg-mg-MP1793-Ab-2 | Anti-Mouse TGFBI monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1793-Ab-1/ GM-Tg-cynog-MP1793-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TGFBI monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1793-Ab-1/ GM-Tg-felg-MP1793-Ab-2 | Anti-Feline TGFBI monoclonal antibody | Feline |
| GM-Tg-cang-MP1793-Ab-1/ GM-Tg-cang-MP1793-Ab-2 | Anti-Canine TGFBI monoclonal antibody | Canine |
| GM-Tg-bovg-MP1793-Ab-1/ GM-Tg-bovg-MP1793-Ab-2 | Anti-Bovine TGFBI monoclonal antibody | Bovine |
| GM-Tg-equg-MP1793-Ab-1/ GM-Tg-equg-MP1793-Ab-2 | Anti-Equine TGFBI monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1793-Ab-1/ GM-Tg-hg-MP1793-Ab-2; GM-Tg-rg-MP1793-Ab-1/ GM-Tg-rg-MP1793-Ab-2; GM-Tg-mg-MP1793-Ab-1/ GM-Tg-mg-MP1793-Ab-2; GM-Tg-cynog-MP1793-Ab-1/ GM-Tg-cynog-MP1793-Ab-2; GM-Tg-felg-MP1793-Ab-1/ GM-Tg-felg-MP1793-Ab-2; GM-Tg-cang-MP1793-Ab-1/ GM-Tg-cang-MP1793-Ab-2; GM-Tg-bovg-MP1793-Ab-1/ GM-Tg-bovg-MP1793-Ab-2; GM-Tg-equg-MP1793-Ab-1/ GM-Tg-equg-MP1793-Ab-2 |
| Products Name | Anti-TGFBI monoclonal antibody |
| Format | mab |
| Target Name | TGFBI |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TGFBI benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BGH3/ TGFBI/ BIGH3 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1793-Ag-1 | transforming growth factor, beta-induced, 68kDa (TGFBI) protein |
| ORF Viral Vector | pGMLP005095 | human TGFBI Lentivirus plasmid |
| ORF Viral Vector | vGMLP005095 | human TGFBI Lentivirus particle |
| ORF Viral Vector | pGMLPm003124 | mouse Tgfbi Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003124 | mouse Tgfbi Lentivirus particle |
Target information
| Target ID | GM-MP1793 |
| Target Name | TGFBI |
| Gene ID | 7045,21810,116487,712503,481519,101081357,539596,100072674 |
| Gene Symbol and Synonyms | 68kDa,Beta-ig,big-h3,BIGH3,CDB1,CDG2,CDGG1,CSD,CSD1,CSD2,CSD3,EBMD,LCD1,MP70,MP78,TGFBI |
| Uniprot Accession | Q15582,P55906 |
| Uniprot Entry Name | BGH3_HUMAN,BGH3_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Pre-eclampsia |
| Gene Ensembl | ENSG00000120708 |
| Target Classification | N/A |
The target: TGFBI, gene name: TGFBI, also named as BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1. This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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