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Anti-TLR10/ CD290 monoclonal antibody
Anti-TLR10/ CD290 antibody for FACS & in-vivo assay
Go to TLR10/TLR10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1801-Ab-1/ GM-Tg-hg-MP1801-Ab-2 | Anti-Human TLR10 monoclonal antibody | Human |
| GM-Tg-rg-MP1801-Ab-1/ GM-Tg-rg-MP1801-Ab-2 | Anti-Rat TLR10 monoclonal antibody | Rat |
| GM-Tg-mg-MP1801-Ab-1/ GM-Tg-mg-MP1801-Ab-2 | Anti-Mouse TLR10 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1801-Ab-1/ GM-Tg-cynog-MP1801-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TLR10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1801-Ab-1/ GM-Tg-felg-MP1801-Ab-2 | Anti-Feline TLR10 monoclonal antibody | Feline |
| GM-Tg-cang-MP1801-Ab-1/ GM-Tg-cang-MP1801-Ab-2 | Anti-Canine TLR10 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1801-Ab-1/ GM-Tg-bovg-MP1801-Ab-2 | Anti-Bovine TLR10 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1801-Ab-1/ GM-Tg-equg-MP1801-Ab-2 | Anti-Equine TLR10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1801-Ab-1/ GM-Tg-hg-MP1801-Ab-2; GM-Tg-rg-MP1801-Ab-1/ GM-Tg-rg-MP1801-Ab-2; GM-Tg-mg-MP1801-Ab-1/ GM-Tg-mg-MP1801-Ab-2; GM-Tg-cynog-MP1801-Ab-1/ GM-Tg-cynog-MP1801-Ab-2; GM-Tg-felg-MP1801-Ab-1/ GM-Tg-felg-MP1801-Ab-2; GM-Tg-cang-MP1801-Ab-1/ GM-Tg-cang-MP1801-Ab-2; GM-Tg-bovg-MP1801-Ab-1/ GM-Tg-bovg-MP1801-Ab-2; GM-Tg-equg-MP1801-Ab-1/ GM-Tg-equg-MP1801-Ab-2 |
| Products Name | Anti-TLR10 monoclonal antibody |
| Format | mab |
| Target Name | TLR10 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TLR10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TLR10/ CD290 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1801 |
| Target Name | TLR10 |
| Gene ID | 81793,305355,697980,100379585,101085543,539791,100064614 |
| Gene Symbol and Synonyms | CD290,TLR10 |
| Uniprot Accession | Q9BXR5,Q6GV17 |
| Uniprot Entry Name | TLR10_HUMAN,TLR10_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000174123 |
| Target Classification | N/A |
The target: TLR10, gene name: TLR10, also named as CD290. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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