Anti-T4S20/ ™4SF20/ PRO994 monoclonal antibody

Anti-T4S20/ ™4SF20/ PRO994 antibody for FACS & in-vivo assay

Target products collectionGo to ™4SF20/™4SF20 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1802-Ab-1/ GM-Tg-hg-MP1802-Ab-2Anti-Human ™4SF20 monoclonal antibodyHuman
GM-Tg-rg-MP1802-Ab-1/ GM-Tg-rg-MP1802-Ab-2Anti-Rat ™4SF20 monoclonal antibodyRat
GM-Tg-mg-MP1802-Ab-1/ GM-Tg-mg-MP1802-Ab-2Anti-Mouse ™4SF20 monoclonal antibodyMouse
GM-Tg-cynog-MP1802-Ab-1/ GM-Tg-cynog-MP1802-Ab-2Anti-Cynomolgus/ Rhesus macaque ™4SF20 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1802-Ab-1/ GM-Tg-felg-MP1802-Ab-2Anti-Feline ™4SF20 monoclonal antibodyFeline
GM-Tg-cang-MP1802-Ab-1/ GM-Tg-cang-MP1802-Ab-2Anti-Canine ™4SF20 monoclonal antibodyCanine
GM-Tg-bovg-MP1802-Ab-1/ GM-Tg-bovg-MP1802-Ab-2Anti-Bovine ™4SF20 monoclonal antibodyBovine
GM-Tg-equg-MP1802-Ab-1/ GM-Tg-equg-MP1802-Ab-2Anti-Equine ™4SF20 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1802-Ab-1/ GM-Tg-hg-MP1802-Ab-2; GM-Tg-rg-MP1802-Ab-1/ GM-Tg-rg-MP1802-Ab-2;
GM-Tg-mg-MP1802-Ab-1/ GM-Tg-mg-MP1802-Ab-2; GM-Tg-cynog-MP1802-Ab-1/ GM-Tg-cynog-MP1802-Ab-2;
GM-Tg-felg-MP1802-Ab-1/ GM-Tg-felg-MP1802-Ab-2; GM-Tg-cang-MP1802-Ab-1/ GM-Tg-cang-MP1802-Ab-2;
GM-Tg-bovg-MP1802-Ab-1/ GM-Tg-bovg-MP1802-Ab-2; GM-Tg-equg-MP1802-Ab-1/ GM-Tg-equg-MP1802-Ab-2
Products NameAnti-™4SF20 monoclonal antibody
Formatmab
Target Name™4SF20
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-™4SF20 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species T4S20/ ™4SF20/ PRO994 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1802
    Target Name™4SF20
    Gene ID79853,66261,691066,708719,609780,101088018,767902,100062336
    Gene Symbol and Synonyms1810018L02Rik,PRO994,SLI5,TCCE518,™4SF20
    Uniprot AccessionQ53R12,Q3T0Z4
    Uniprot Entry NameT4S20_HUMAN,T4S20_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000168955
    Target ClassificationN/A

    The target: ™4SF20, gene name: ™4SF20, also named as PRO994, SLI5, TCCE518. The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.