Anti-™C6/ EV1/ EVER1 monoclonal antibody

Anti-™C6/ EV1/ EVER1 antibody for FACS & in-vivo assay

Target products collectionGo to ™C6/™C6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1806-Ab-1/ GM-Tg-hg-MP1806-Ab-2Anti-Human ™C6 monoclonal antibodyHuman
GM-Tg-rg-MP1806-Ab-1/ GM-Tg-rg-MP1806-Ab-2Anti-Rat ™C6 monoclonal antibodyRat
GM-Tg-mg-MP1806-Ab-1/ GM-Tg-mg-MP1806-Ab-2Anti-Mouse ™C6 monoclonal antibodyMouse
GM-Tg-cynog-MP1806-Ab-1/ GM-Tg-cynog-MP1806-Ab-2Anti-Cynomolgus/ Rhesus macaque ™C6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1806-Ab-1/ GM-Tg-felg-MP1806-Ab-2Anti-Feline ™C6 monoclonal antibodyFeline
GM-Tg-cang-MP1806-Ab-1/ GM-Tg-cang-MP1806-Ab-2Anti-Canine ™C6 monoclonal antibodyCanine
GM-Tg-bovg-MP1806-Ab-1/ GM-Tg-bovg-MP1806-Ab-2Anti-Bovine ™C6 monoclonal antibodyBovine
GM-Tg-equg-MP1806-Ab-1/ GM-Tg-equg-MP1806-Ab-2Anti-Equine ™C6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1806-Ab-1/ GM-Tg-hg-MP1806-Ab-2; GM-Tg-rg-MP1806-Ab-1/ GM-Tg-rg-MP1806-Ab-2;
GM-Tg-mg-MP1806-Ab-1/ GM-Tg-mg-MP1806-Ab-2; GM-Tg-cynog-MP1806-Ab-1/ GM-Tg-cynog-MP1806-Ab-2;
GM-Tg-felg-MP1806-Ab-1/ GM-Tg-felg-MP1806-Ab-2; GM-Tg-cang-MP1806-Ab-1/ GM-Tg-cang-MP1806-Ab-2;
GM-Tg-bovg-MP1806-Ab-1/ GM-Tg-bovg-MP1806-Ab-2; GM-Tg-equg-MP1806-Ab-1/ GM-Tg-equg-MP1806-Ab-2
Products NameAnti-™C6 monoclonal antibody
Formatmab
Target Name™C6
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-™C6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ™C6/ EV1/ EVER1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1806
    Target Name™C6
    Gene ID11322,217353,688280,714977,483341,101080340,505575,100058089
    Gene Symbol and SynonymsAABR07030861.1,D11Ertd204e,EV1,EVER1,EVIN1,LAK-4P,lnc,™C6,TNRC6C-AS1
    Uniprot AccessionQ7Z403
    Uniprot Entry Name™C6_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000141524
    Target ClassificationN/A

    The target: ™C6, gene name: ™C6, also named as EV1, EVER1, EVIN1, LAK-4P. Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.