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Anti-™X3/ PDIA13/ TXNDC10 monoclonal antibody
Anti-™X3/ PDIA13/ TXNDC10 antibody for FACS & in-vivo assay
Go to ™X3/™X3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1853-Ab-1/ GM-Tg-hg-MP1853-Ab-2 | Anti-Human ™X3 monoclonal antibody | Human |
| GM-Tg-rg-MP1853-Ab-1/ GM-Tg-rg-MP1853-Ab-2 | Anti-Rat ™X3 monoclonal antibody | Rat |
| GM-Tg-mg-MP1853-Ab-1/ GM-Tg-mg-MP1853-Ab-2 | Anti-Mouse ™X3 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1853-Ab-1/ GM-Tg-cynog-MP1853-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™X3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1853-Ab-1/ GM-Tg-felg-MP1853-Ab-2 | Anti-Feline ™X3 monoclonal antibody | Feline |
| GM-Tg-cang-MP1853-Ab-1/ GM-Tg-cang-MP1853-Ab-2 | Anti-Canine ™X3 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1853-Ab-1/ GM-Tg-bovg-MP1853-Ab-2 | Anti-Bovine ™X3 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1853-Ab-1/ GM-Tg-equg-MP1853-Ab-2 | Anti-Equine ™X3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1853-Ab-1/ GM-Tg-hg-MP1853-Ab-2; GM-Tg-rg-MP1853-Ab-1/ GM-Tg-rg-MP1853-Ab-2; GM-Tg-mg-MP1853-Ab-1/ GM-Tg-mg-MP1853-Ab-2; GM-Tg-cynog-MP1853-Ab-1/ GM-Tg-cynog-MP1853-Ab-2; GM-Tg-felg-MP1853-Ab-1/ GM-Tg-felg-MP1853-Ab-2; GM-Tg-cang-MP1853-Ab-1/ GM-Tg-cang-MP1853-Ab-2; GM-Tg-bovg-MP1853-Ab-1/ GM-Tg-bovg-MP1853-Ab-2; GM-Tg-equg-MP1853-Ab-1/ GM-Tg-equg-MP1853-Ab-2 |
| Products Name | Anti-™X3 monoclonal antibody |
| Format | mab |
| Target Name | ™X3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-™X3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ™X3/ PDIA13/ TXNDC10 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003720 | human ™X3 Lentivirus particle |
| ORF Viral Vector | pGMLP003720 | human ™X3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001457 | mouse Tmx3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001457 | mouse Tmx3 Lentivirus particle |
Target information
| Target ID | GM-MP1853 |
| Target Name | ™X3 |
| Gene ID | 54495,67988,682967,710611,476176,101087107,615687,100051906 |
| Gene Symbol and Synonyms | 6430411B10Rik,A730024F05Rik,mKIAA1830,PDIA13,™X3,TXNDC10 |
| Uniprot Accession | Q96JJ7 |
| Uniprot Entry Name | ™X3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166479 |
| Target Classification | N/A |
The target: ™X3, gene name: ™X3, also named as PDIA13, TXNDC10. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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