Anti-TR10D/ TNFRSF10D/ CD264 monoclonal antibody

Anti-TR10D/ TNFRSF10D/ CD264 antibody for FACS & in-vivo assay

Target products collectionGo to TNFRSF10D/TNFRSF10D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1855-Ab-1/ GM-Tg-hg-MP1855-Ab-2Anti-Human TNFRSF10D monoclonal antibodyHuman
GM-Tg-rg-MP1855-Ab-1/ GM-Tg-rg-MP1855-Ab-2Anti-Rat TNFRSF10D monoclonal antibodyRat
GM-Tg-mg-MP1855-Ab-1/ GM-Tg-mg-MP1855-Ab-2Anti-Mouse TNFRSF10D monoclonal antibodyMouse
GM-Tg-cynog-MP1855-Ab-1/ GM-Tg-cynog-MP1855-Ab-2Anti-Cynomolgus/ Rhesus macaque TNFRSF10D monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1855-Ab-1/ GM-Tg-felg-MP1855-Ab-2Anti-Feline TNFRSF10D monoclonal antibodyFeline
GM-Tg-cang-MP1855-Ab-1/ GM-Tg-cang-MP1855-Ab-2Anti-Canine TNFRSF10D monoclonal antibodyCanine
GM-Tg-bovg-MP1855-Ab-1/ GM-Tg-bovg-MP1855-Ab-2Anti-Bovine TNFRSF10D monoclonal antibodyBovine
GM-Tg-equg-MP1855-Ab-1/ GM-Tg-equg-MP1855-Ab-2Anti-Equine TNFRSF10D monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1855-Ab-1/ GM-Tg-hg-MP1855-Ab-2; GM-Tg-rg-MP1855-Ab-1/ GM-Tg-rg-MP1855-Ab-2;
GM-Tg-mg-MP1855-Ab-1/ GM-Tg-mg-MP1855-Ab-2; GM-Tg-cynog-MP1855-Ab-1/ GM-Tg-cynog-MP1855-Ab-2;
GM-Tg-felg-MP1855-Ab-1/ GM-Tg-felg-MP1855-Ab-2; GM-Tg-cang-MP1855-Ab-1/ GM-Tg-cang-MP1855-Ab-2;
GM-Tg-bovg-MP1855-Ab-1/ GM-Tg-bovg-MP1855-Ab-2; GM-Tg-equg-MP1855-Ab-1/ GM-Tg-equg-MP1855-Ab-2
Products NameAnti-TNFRSF10D monoclonal antibody
Formatmab
Target NameTNFRSF10D
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFRSF10D benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TR10D/ TNFRSF10D/ CD264 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003625human TNFRSF10D Lentivirus plasmid
    ORF Viral VectorvGMLP003625human TNFRSF10D Lentivirus particle


    Target information

    Target IDGM-MP1855
    Target NameTNFRSF10D
    Gene ID8793,716901
    Gene Symbol and SynonymsCD264,DCR2,TNFRSF10D,TRAIL-R4,TRAILR4,TRUNDD
    Uniprot AccessionQ9UBN6
    Uniprot Entry NameTR10D_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000173530
    Target ClassificationTumor-associated antigen (TAA)

    The target: TNFRSF10D, gene name: TNFRSF10D, also named as CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.