Anti-TRDN/ CPVT5/ TDN monoclonal antibody

Anti-TRDN/ CPVT5/ TDN antibody for FACS & in-vivo assay

Target products collectionGo to TRDN/TRDN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1871-Ab-1/ GM-Tg-hg-MP1871-Ab-2Anti-Human TRDN monoclonal antibodyHuman
GM-Tg-rg-MP1871-Ab-1/ GM-Tg-rg-MP1871-Ab-2Anti-Rat TRDN monoclonal antibodyRat
GM-Tg-mg-MP1871-Ab-1/ GM-Tg-mg-MP1871-Ab-2Anti-Mouse TRDN monoclonal antibodyMouse
GM-Tg-cynog-MP1871-Ab-1/ GM-Tg-cynog-MP1871-Ab-2Anti-Cynomolgus/ Rhesus macaque TRDN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1871-Ab-1/ GM-Tg-felg-MP1871-Ab-2Anti-Feline TRDN monoclonal antibodyFeline
GM-Tg-cang-MP1871-Ab-1/ GM-Tg-cang-MP1871-Ab-2Anti-Canine TRDN monoclonal antibodyCanine
GM-Tg-bovg-MP1871-Ab-1/ GM-Tg-bovg-MP1871-Ab-2Anti-Bovine TRDN monoclonal antibodyBovine
GM-Tg-equg-MP1871-Ab-1/ GM-Tg-equg-MP1871-Ab-2Anti-Equine TRDN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1871-Ab-1/ GM-Tg-hg-MP1871-Ab-2; GM-Tg-rg-MP1871-Ab-1/ GM-Tg-rg-MP1871-Ab-2;
GM-Tg-mg-MP1871-Ab-1/ GM-Tg-mg-MP1871-Ab-2; GM-Tg-cynog-MP1871-Ab-1/ GM-Tg-cynog-MP1871-Ab-2;
GM-Tg-felg-MP1871-Ab-1/ GM-Tg-felg-MP1871-Ab-2; GM-Tg-cang-MP1871-Ab-1/ GM-Tg-cang-MP1871-Ab-2;
GM-Tg-bovg-MP1871-Ab-1/ GM-Tg-bovg-MP1871-Ab-2; GM-Tg-equg-MP1871-Ab-1/ GM-Tg-equg-MP1871-Ab-2
Products NameAnti-TRDN monoclonal antibody
Formatmab
Target NameTRDN
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TRDN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TRDN/ CPVT5/ TDN VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1871
    Target NameTRDN
    Gene ID10345,76757,59299,403776,101082911,100072982
    Gene Symbol and Synonyms2310045H21Rik,CARDAR,CPVT5,EG432451,TDN,TRDN,TRISK
    Uniprot AccessionQ13061,Q9QX75,P82179
    Uniprot Entry NameTRDN_HUMAN,TRDN_RAT,TRDN_CANLF
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000186439
    Target ClassificationN/A

    The target: TRDN, gene name: TRDN, also named as CPVT5, TDN, TRISK. This gene encodes an integral membrane protein found in skeletal and cardiac muscle. The encoded protein plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex and is required for normal skeletal muscle strength. This protein indirectly links triads and microtubules in skeletal muscle. Mutations in this gene are associated with cardiac arrythmia syndrome and some variants in this gene may be associated with sudden cardiac death. [provided by RefSeq, May 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.