Anti-TRML4/ TREML4/ TLT-4 monoclonal antibody

Anti-TRML4/ TREML4/ TLT-4 antibody for FACS & in-vivo assay

Target products collectionGo to TREML4/TREML4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1874-Ab-1/ GM-Tg-hg-MP1874-Ab-2Anti-Human TREML4 monoclonal antibodyHuman
GM-Tg-rg-MP1874-Ab-1/ GM-Tg-rg-MP1874-Ab-2Anti-Rat TREML4 monoclonal antibodyRat
GM-Tg-mg-MP1874-Ab-1/ GM-Tg-mg-MP1874-Ab-2Anti-Mouse TREML4 monoclonal antibodyMouse
GM-Tg-cynog-MP1874-Ab-1/ GM-Tg-cynog-MP1874-Ab-2Anti-Cynomolgus/ Rhesus macaque TREML4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1874-Ab-1/ GM-Tg-felg-MP1874-Ab-2Anti-Feline TREML4 monoclonal antibodyFeline
GM-Tg-cang-MP1874-Ab-1/ GM-Tg-cang-MP1874-Ab-2Anti-Canine TREML4 monoclonal antibodyCanine
GM-Tg-bovg-MP1874-Ab-1/ GM-Tg-bovg-MP1874-Ab-2Anti-Bovine TREML4 monoclonal antibodyBovine
GM-Tg-equg-MP1874-Ab-1/ GM-Tg-equg-MP1874-Ab-2Anti-Equine TREML4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1874-Ab-1/ GM-Tg-hg-MP1874-Ab-2; GM-Tg-rg-MP1874-Ab-1/ GM-Tg-rg-MP1874-Ab-2;
GM-Tg-mg-MP1874-Ab-1/ GM-Tg-mg-MP1874-Ab-2; GM-Tg-cynog-MP1874-Ab-1/ GM-Tg-cynog-MP1874-Ab-2;
GM-Tg-felg-MP1874-Ab-1/ GM-Tg-felg-MP1874-Ab-2; GM-Tg-cang-MP1874-Ab-1/ GM-Tg-cang-MP1874-Ab-2;
GM-Tg-bovg-MP1874-Ab-1/ GM-Tg-bovg-MP1874-Ab-2; GM-Tg-equg-MP1874-Ab-1/ GM-Tg-equg-MP1874-Ab-2
Products NameAnti-TREML4 monoclonal antibody
Formatmab
Target NameTREML4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TREML4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TRML4/ TREML4/ TLT-4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1874
    Target NameTREML4
    Gene ID285852,100423370
    Gene Symbol and SynonymsTLT-4,TLT4,TREML4
    Uniprot AccessionQ6UXN2
    Uniprot Entry NameTRML4_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000188056
    Target ClassificationN/A

    The target: TREML4, gene name: TREML4, also named as TLT-4, TLT4. Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface. Predicted to colocalize with endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.