Anti-TTYH1 monoclonal antibody

Anti-TTYH1 antibody for FACS & in-vivo assay

Target products collectionGo to TTYH1/TTYH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1891-Ab-1/ GM-Tg-hg-MP1891-Ab-2Anti-Human TTYH1 monoclonal antibodyHuman
GM-Tg-rg-MP1891-Ab-1/ GM-Tg-rg-MP1891-Ab-2Anti-Rat TTYH1 monoclonal antibodyRat
GM-Tg-mg-MP1891-Ab-1/ GM-Tg-mg-MP1891-Ab-2Anti-Mouse TTYH1 monoclonal antibodyMouse
GM-Tg-cynog-MP1891-Ab-1/ GM-Tg-cynog-MP1891-Ab-2Anti-Cynomolgus/ Rhesus macaque TTYH1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1891-Ab-1/ GM-Tg-felg-MP1891-Ab-2Anti-Feline TTYH1 monoclonal antibodyFeline
GM-Tg-cang-MP1891-Ab-1/ GM-Tg-cang-MP1891-Ab-2Anti-Canine TTYH1 monoclonal antibodyCanine
GM-Tg-bovg-MP1891-Ab-1/ GM-Tg-bovg-MP1891-Ab-2Anti-Bovine TTYH1 monoclonal antibodyBovine
GM-Tg-equg-MP1891-Ab-1/ GM-Tg-equg-MP1891-Ab-2Anti-Equine TTYH1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1891-Ab-1/ GM-Tg-hg-MP1891-Ab-2; GM-Tg-rg-MP1891-Ab-1/ GM-Tg-rg-MP1891-Ab-2;
GM-Tg-mg-MP1891-Ab-1/ GM-Tg-mg-MP1891-Ab-2; GM-Tg-cynog-MP1891-Ab-1/ GM-Tg-cynog-MP1891-Ab-2;
GM-Tg-felg-MP1891-Ab-1/ GM-Tg-felg-MP1891-Ab-2; GM-Tg-cang-MP1891-Ab-1/ GM-Tg-cang-MP1891-Ab-2;
GM-Tg-bovg-MP1891-Ab-1/ GM-Tg-bovg-MP1891-Ab-2; GM-Tg-equg-MP1891-Ab-1/ GM-Tg-equg-MP1891-Ab-2
Products NameAnti-TTYH1 monoclonal antibody
Formatmab
Target NameTTYH1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TTYH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TTYH1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1891
    Target NameTTYH1
    Gene ID57348,57776,292597,695643,476386,101095059,767943,100053883
    Gene Symbol and Synonyms4930459B04Rik,6330408P11Rik,mTTY1,tty,TTY1,TTYH1
    Uniprot AccessionQ9H313,P0C5X8,Q2KJ98
    Uniprot Entry NameTTYH1_HUMAN,TTYH1_RAT,TTYH1_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000167614
    Target ClassificationIon Channel

    The target: TTYH1, gene name: TTYH1, also named as . This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.