Anti-TTYH2/ C17orf29 monoclonal antibody

Anti-TTYH2/ C17orf29 antibody for FACS & in-vivo assay

Target products collectionGo to TTYH2/TTYH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1892-Ab-1/ GM-Tg-hg-MP1892-Ab-2Anti-Human TTYH2 monoclonal antibodyHuman
GM-Tg-rg-MP1892-Ab-1/ GM-Tg-rg-MP1892-Ab-2Anti-Rat TTYH2 monoclonal antibodyRat
GM-Tg-mg-MP1892-Ab-1/ GM-Tg-mg-MP1892-Ab-2Anti-Mouse TTYH2 monoclonal antibodyMouse
GM-Tg-cynog-MP1892-Ab-1/ GM-Tg-cynog-MP1892-Ab-2Anti-Cynomolgus/ Rhesus macaque TTYH2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1892-Ab-1/ GM-Tg-felg-MP1892-Ab-2Anti-Feline TTYH2 monoclonal antibodyFeline
GM-Tg-cang-MP1892-Ab-1/ GM-Tg-cang-MP1892-Ab-2Anti-Canine TTYH2 monoclonal antibodyCanine
GM-Tg-bovg-MP1892-Ab-1/ GM-Tg-bovg-MP1892-Ab-2Anti-Bovine TTYH2 monoclonal antibodyBovine
GM-Tg-equg-MP1892-Ab-1/ GM-Tg-equg-MP1892-Ab-2Anti-Equine TTYH2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1892-Ab-1/ GM-Tg-hg-MP1892-Ab-2; GM-Tg-rg-MP1892-Ab-1/ GM-Tg-rg-MP1892-Ab-2;
GM-Tg-mg-MP1892-Ab-1/ GM-Tg-mg-MP1892-Ab-2; GM-Tg-cynog-MP1892-Ab-1/ GM-Tg-cynog-MP1892-Ab-2;
GM-Tg-felg-MP1892-Ab-1/ GM-Tg-felg-MP1892-Ab-2; GM-Tg-cang-MP1892-Ab-1/ GM-Tg-cang-MP1892-Ab-2;
GM-Tg-bovg-MP1892-Ab-1/ GM-Tg-bovg-MP1892-Ab-2; GM-Tg-equg-MP1892-Ab-1/ GM-Tg-equg-MP1892-Ab-2
Products NameAnti-TTYH2 monoclonal antibody
Formatmab
Target NameTTYH2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TTYH2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TTYH2/ C17orf29 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1892
    Target NameTTYH2
    Gene ID94015,117160,287803,701738,106559221,101095532,533184,100060986
    Gene Symbol and Synonyms1110001A03Rik,C17orf29,RGD1562969,TTYH2
    Uniprot AccessionQ9BSA4
    Uniprot Entry NameTTYH2_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000141540
    Target ClassificationIon Channel

    The target: TTYH2, gene name: TTYH2, also named as C17orf29. This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.