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Anti-TYOBP/ TYROBP/ DAP12 monoclonal antibody
Anti-TYOBP/ TYROBP/ DAP12 antibody for FACS & in-vivo assay
Go to TYROBP/TYROBP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1895-Ab-1/ GM-Tg-hg-MP1895-Ab-2 | Anti-Human TYROBP monoclonal antibody | Human |
| GM-Tg-rg-MP1895-Ab-1/ GM-Tg-rg-MP1895-Ab-2 | Anti-Rat TYROBP monoclonal antibody | Rat |
| GM-Tg-mg-MP1895-Ab-1/ GM-Tg-mg-MP1895-Ab-2 | Anti-Mouse TYROBP monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1895-Ab-1/ GM-Tg-cynog-MP1895-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TYROBP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1895-Ab-1/ GM-Tg-felg-MP1895-Ab-2 | Anti-Feline TYROBP monoclonal antibody | Feline |
| GM-Tg-cang-MP1895-Ab-1/ GM-Tg-cang-MP1895-Ab-2 | Anti-Canine TYROBP monoclonal antibody | Canine |
| GM-Tg-bovg-MP1895-Ab-1/ GM-Tg-bovg-MP1895-Ab-2 | Anti-Bovine TYROBP monoclonal antibody | Bovine |
| GM-Tg-equg-MP1895-Ab-1/ GM-Tg-equg-MP1895-Ab-2 | Anti-Equine TYROBP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1895-Ab-1/ GM-Tg-hg-MP1895-Ab-2; GM-Tg-rg-MP1895-Ab-1/ GM-Tg-rg-MP1895-Ab-2; GM-Tg-mg-MP1895-Ab-1/ GM-Tg-mg-MP1895-Ab-2; GM-Tg-cynog-MP1895-Ab-1/ GM-Tg-cynog-MP1895-Ab-2; GM-Tg-felg-MP1895-Ab-1/ GM-Tg-felg-MP1895-Ab-2; GM-Tg-cang-MP1895-Ab-1/ GM-Tg-cang-MP1895-Ab-2; GM-Tg-bovg-MP1895-Ab-1/ GM-Tg-bovg-MP1895-Ab-2; GM-Tg-equg-MP1895-Ab-1/ GM-Tg-equg-MP1895-Ab-2 |
| Products Name | Anti-TYROBP monoclonal antibody |
| Format | mab |
| Target Name | TYROBP |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TYROBP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TYOBP/ TYROBP/ DAP12 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002996 | human TYROBP Lentivirus particle |
| ORF Viral Vector | pGMLP002996 | human TYROBP Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001878 | mouse Tyrobp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001878 | mouse Tyrobp Lentivirus particle |
Target information
| Target ID | GM-MP1895 |
| Target Name | TYROBP |
| Gene ID | 7305,22177,361537,574207,476477,101082964,282390,100051740 |
| Gene Symbol and Synonyms | DAP12,KARAP,Ly83,PLOSL,PLOSL1,TYROBP |
| Uniprot Accession | O43914,Q6X9T7,Q8WNQ8,Q95J79 |
| Uniprot Entry Name | TYOBP_HUMAN,TYOBP_MACMU,TYOBP_RAT,TYOBP_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000011600 |
| Target Classification | N/A |
The target: TYROBP, gene name: TYROBP, also named as DAP12, KARAP, PLOSL. This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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