Anti-CGT/ UGT8/ UGT4 monoclonal antibody

Anti-CGT/ UGT8/ UGT4 antibody for FACS & in-vivo assay

Target products collectionGo to UGT8/UGT8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1897-Ab-1/ GM-Tg-hg-MP1897-Ab-2Anti-Human UGT8 monoclonal antibodyHuman
GM-Tg-rg-MP1897-Ab-1/ GM-Tg-rg-MP1897-Ab-2Anti-Rat UGT8 monoclonal antibodyRat
GM-Tg-mg-MP1897-Ab-1/ GM-Tg-mg-MP1897-Ab-2Anti-Mouse UGT8 monoclonal antibodyMouse
GM-Tg-cynog-MP1897-Ab-1/ GM-Tg-cynog-MP1897-Ab-2Anti-Cynomolgus/ Rhesus macaque UGT8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1897-Ab-1/ GM-Tg-felg-MP1897-Ab-2Anti-Feline UGT8 monoclonal antibodyFeline
GM-Tg-cang-MP1897-Ab-1/ GM-Tg-cang-MP1897-Ab-2Anti-Canine UGT8 monoclonal antibodyCanine
GM-Tg-bovg-MP1897-Ab-1/ GM-Tg-bovg-MP1897-Ab-2Anti-Bovine UGT8 monoclonal antibodyBovine
GM-Tg-equg-MP1897-Ab-1/ GM-Tg-equg-MP1897-Ab-2Anti-Equine UGT8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1897-Ab-1/ GM-Tg-hg-MP1897-Ab-2; GM-Tg-rg-MP1897-Ab-1/ GM-Tg-rg-MP1897-Ab-2;
GM-Tg-mg-MP1897-Ab-1/ GM-Tg-mg-MP1897-Ab-2; GM-Tg-cynog-MP1897-Ab-1/ GM-Tg-cynog-MP1897-Ab-2;
GM-Tg-felg-MP1897-Ab-1/ GM-Tg-felg-MP1897-Ab-2; GM-Tg-cang-MP1897-Ab-1/ GM-Tg-cang-MP1897-Ab-2;
GM-Tg-bovg-MP1897-Ab-1/ GM-Tg-bovg-MP1897-Ab-2; GM-Tg-equg-MP1897-Ab-1/ GM-Tg-equg-MP1897-Ab-2
Products NameAnti-UGT8 monoclonal antibody
Formatmab
Target NameUGT8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-UGT8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CGT/ UGT8/ UGT4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1897
    Target NameUGT8
    Gene ID7368,22239,50555,702979,487910,101097722,281566,100072587
    Gene Symbol and SynonymsCGalT,CGT,mCerGT,UGT4,UGT8,Ugt8a
    Uniprot AccessionQ16880,Q09426
    Uniprot Entry NameCGT_HUMAN,CGT_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000174607
    Target ClassificationN/A

    The target: UGT8, gene name: UGT8, also named as CGT, UGT4. The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.