Anti-ULBP3/ N2DL-3/ NKG2DL3 monoclonal antibody

Anti-ULBP3/ N2DL-3/ NKG2DL3 antibody for FACS & in-vivo assay

Target products collectionGo to ULBP3/ULBP3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1900-Ab-1/ GM-Tg-hg-MP1900-Ab-2Anti-Human ULBP3 monoclonal antibodyHuman
GM-Tg-rg-MP1900-Ab-1/ GM-Tg-rg-MP1900-Ab-2Anti-Rat ULBP3 monoclonal antibodyRat
GM-Tg-mg-MP1900-Ab-1/ GM-Tg-mg-MP1900-Ab-2Anti-Mouse ULBP3 monoclonal antibodyMouse
GM-Tg-cynog-MP1900-Ab-1/ GM-Tg-cynog-MP1900-Ab-2Anti-Cynomolgus/ Rhesus macaque ULBP3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1900-Ab-1/ GM-Tg-felg-MP1900-Ab-2Anti-Feline ULBP3 monoclonal antibodyFeline
GM-Tg-cang-MP1900-Ab-1/ GM-Tg-cang-MP1900-Ab-2Anti-Canine ULBP3 monoclonal antibodyCanine
GM-Tg-bovg-MP1900-Ab-1/ GM-Tg-bovg-MP1900-Ab-2Anti-Bovine ULBP3 monoclonal antibodyBovine
GM-Tg-equg-MP1900-Ab-1/ GM-Tg-equg-MP1900-Ab-2Anti-Equine ULBP3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1900-Ab-1/ GM-Tg-hg-MP1900-Ab-2; GM-Tg-rg-MP1900-Ab-1/ GM-Tg-rg-MP1900-Ab-2;
GM-Tg-mg-MP1900-Ab-1/ GM-Tg-mg-MP1900-Ab-2; GM-Tg-cynog-MP1900-Ab-1/ GM-Tg-cynog-MP1900-Ab-2;
GM-Tg-felg-MP1900-Ab-1/ GM-Tg-felg-MP1900-Ab-2; GM-Tg-cang-MP1900-Ab-1/ GM-Tg-cang-MP1900-Ab-2;
GM-Tg-bovg-MP1900-Ab-1/ GM-Tg-bovg-MP1900-Ab-2; GM-Tg-equg-MP1900-Ab-1/ GM-Tg-equg-MP1900-Ab-2
Products NameAnti-ULBP3 monoclonal antibody
Formatmab
Target NameULBP3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ULBP3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ULBP3/ N2DL-3/ NKG2DL3 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1900
    Target NameULBP3
    Gene ID79465
    Gene Symbol and SynonymsN2DL-3,NKG2DL3,RAET1N,ULBP3
    Uniprot AccessionQ9BZM4
    Uniprot Entry NameULBP3_HUMAN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000131019
    Target ClassificationN/A

    The target: ULBP3, gene name: ULBP3, also named as N2DL-3, NKG2DL3, RAET1N. The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.