- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-UNC5C/ UNC5H3 monoclonal antibody
Anti-UNC5C/ UNC5H3 antibody for FACS & in-vivo assay
Go to UNC5C/UNC5C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1903-Ab-1/ GM-Tg-hg-MP1903-Ab-2 | Anti-Human UNC5C monoclonal antibody | Human |
| GM-Tg-rg-MP1903-Ab-1/ GM-Tg-rg-MP1903-Ab-2 | Anti-Rat UNC5C monoclonal antibody | Rat |
| GM-Tg-mg-MP1903-Ab-1/ GM-Tg-mg-MP1903-Ab-2 | Anti-Mouse UNC5C monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1903-Ab-1/ GM-Tg-cynog-MP1903-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UNC5C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1903-Ab-1/ GM-Tg-felg-MP1903-Ab-2 | Anti-Feline UNC5C monoclonal antibody | Feline |
| GM-Tg-cang-MP1903-Ab-1/ GM-Tg-cang-MP1903-Ab-2 | Anti-Canine UNC5C monoclonal antibody | Canine |
| GM-Tg-bovg-MP1903-Ab-1/ GM-Tg-bovg-MP1903-Ab-2 | Anti-Bovine UNC5C monoclonal antibody | Bovine |
| GM-Tg-equg-MP1903-Ab-1/ GM-Tg-equg-MP1903-Ab-2 | Anti-Equine UNC5C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1903-Ab-1/ GM-Tg-hg-MP1903-Ab-2; GM-Tg-rg-MP1903-Ab-1/ GM-Tg-rg-MP1903-Ab-2; GM-Tg-mg-MP1903-Ab-1/ GM-Tg-mg-MP1903-Ab-2; GM-Tg-cynog-MP1903-Ab-1/ GM-Tg-cynog-MP1903-Ab-2; GM-Tg-felg-MP1903-Ab-1/ GM-Tg-felg-MP1903-Ab-2; GM-Tg-cang-MP1903-Ab-1/ GM-Tg-cang-MP1903-Ab-2; GM-Tg-bovg-MP1903-Ab-1/ GM-Tg-bovg-MP1903-Ab-2; GM-Tg-equg-MP1903-Ab-1/ GM-Tg-equg-MP1903-Ab-2 |
| Products Name | Anti-UNC5C monoclonal antibody |
| Format | mab |
| Target Name | UNC5C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-UNC5C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species UNC5C/ UNC5H3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-MP1903 |
| Target Name | UNC5C |
| Gene ID | 8633,22253,362049,705591,478485,101081887,533256,100065541 |
| Gene Symbol and Synonyms | B130051O18Rik,rcm,UNC5C,UNC5H3 |
| Uniprot Accession | O95185,Q761X5 |
| Uniprot Entry Name | UNC5C_HUMAN,UNC5C_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000182168 |
| Target Classification | N/A |
The target: UNC5C, gene name: UNC5C, also named as UNC5H3. This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
