Anti-VEZA/ VEZT/ VEZATIN monoclonal antibody

Anti-VEZA/ VEZT/ VEZATIN antibody for FACS & in-vivo assay

Target products collectionGo to VEZT/VEZT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1920-Ab-1/ GM-Tg-hg-MP1920-Ab-2Anti-Human VEZT monoclonal antibodyHuman
GM-Tg-rg-MP1920-Ab-1/ GM-Tg-rg-MP1920-Ab-2Anti-Rat VEZT monoclonal antibodyRat
GM-Tg-mg-MP1920-Ab-1/ GM-Tg-mg-MP1920-Ab-2Anti-Mouse VEZT monoclonal antibodyMouse
GM-Tg-cynog-MP1920-Ab-1/ GM-Tg-cynog-MP1920-Ab-2Anti-Cynomolgus/ Rhesus macaque VEZT monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1920-Ab-1/ GM-Tg-felg-MP1920-Ab-2Anti-Feline VEZT monoclonal antibodyFeline
GM-Tg-cang-MP1920-Ab-1/ GM-Tg-cang-MP1920-Ab-2Anti-Canine VEZT monoclonal antibodyCanine
GM-Tg-bovg-MP1920-Ab-1/ GM-Tg-bovg-MP1920-Ab-2Anti-Bovine VEZT monoclonal antibodyBovine
GM-Tg-equg-MP1920-Ab-1/ GM-Tg-equg-MP1920-Ab-2Anti-Equine VEZT monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1920-Ab-1/ GM-Tg-hg-MP1920-Ab-2; GM-Tg-rg-MP1920-Ab-1/ GM-Tg-rg-MP1920-Ab-2;
GM-Tg-mg-MP1920-Ab-1/ GM-Tg-mg-MP1920-Ab-2; GM-Tg-cynog-MP1920-Ab-1/ GM-Tg-cynog-MP1920-Ab-2;
GM-Tg-felg-MP1920-Ab-1/ GM-Tg-felg-MP1920-Ab-2; GM-Tg-cang-MP1920-Ab-1/ GM-Tg-cang-MP1920-Ab-2;
GM-Tg-bovg-MP1920-Ab-1/ GM-Tg-bovg-MP1920-Ab-2; GM-Tg-equg-MP1920-Ab-1/ GM-Tg-equg-MP1920-Ab-2
Products NameAnti-VEZT monoclonal antibody
Formatmab
Target NameVEZT
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-VEZT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species VEZA/ VEZT/ VEZATIN VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-MP1920
    Target NameVEZT
    Gene ID55591,215008,299738,716675,111090044,101082419,111771075
    Gene Symbol and SynonymsA630071D13Rik,VEZATIN,VEZT
    Uniprot AccessionQ9HBM0,Q5XI52
    Uniprot Entry NameVEZA_HUMAN,VEZA_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000028203
    Target ClassificationN/A

    The target: VEZT, gene name: VEZT, also named as VEZATIN. This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.